Functional implications of CaMKII alternative splicing.
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| Title: | Functional implications of CaMKII alternative splicing. |
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| Authors: | Sloutsky, Roman (AUTHOR), Stratton, Margaret M. (AUTHOR) |
| Source: | European Journal of Neuroscience. Oct2021, Vol. 54 Issue 8, p6780-6794. 15p. 4 Diagrams, 1 Chart. |
| Subjects: | Alternative RNA splicing, Long-term potentiation, Protein kinases, Calmodulin, Synapses, Human genes |
| Abstract: | Ca2+/calmodulin‐dependent protein kinase II (CaMKII) is known to be a crucial regulator in the post‐synapse during long‐term potentiation. This important protein has been the subject of many studies centered on understanding memory at the molecular, cellular, and organismic level. CaMKII is encoded by four genes in humans, all of which undergo alternative splicing at the RNA level, leading to an enormous diversity of expressed proteins. Advances in sequencing technologies have facilitated the discovery of many new CaMKII transcripts. To date, newly discovered CaMKII transcripts have been incorporated into an ambiguous naming scheme. Herein, we review the initial experiments leading to the discovery of CaMKII and its subsequent variants. We propose the adoption of a new, unambiguous naming scheme for CaMKII variants. Finally, we discuss biological implications for CaMKII splice variants. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 153299400 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Functional implications of CaMKII alternative splicing. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Sloutsky%2C+Roman%22">Sloutsky, Roman</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stratton%2C+Margaret+M%2E%22">Stratton, Margaret M.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Journal+of+Neuroscience%22">European Journal of Neuroscience</searchLink>. Oct2021, Vol. 54 Issue 8, p6780-6794. 15p. 4 Diagrams, 1 Chart. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Alternative+RNA+splicing%22">Alternative RNA splicing</searchLink><br /><searchLink fieldCode="DE" term="%22Long-term+potentiation%22">Long-term potentiation</searchLink><br /><searchLink fieldCode="DE" term="%22Protein+kinases%22">Protein kinases</searchLink><br /><searchLink fieldCode="DE" term="%22Calmodulin%22">Calmodulin</searchLink><br /><searchLink fieldCode="DE" term="%22Synapses%22">Synapses</searchLink><br /><searchLink fieldCode="DE" term="%22Human+genes%22">Human genes</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Ca2+/calmodulin‐dependent protein kinase II (CaMKII) is known to be a crucial regulator in the post‐synapse during long‐term potentiation. This important protein has been the subject of many studies centered on understanding memory at the molecular, cellular, and organismic level. CaMKII is encoded by four genes in humans, all of which undergo alternative splicing at the RNA level, leading to an enormous diversity of expressed proteins. Advances in sequencing technologies have facilitated the discovery of many new CaMKII transcripts. To date, newly discovered CaMKII transcripts have been incorporated into an ambiguous naming scheme. Herein, we review the initial experiments leading to the discovery of CaMKII and its subsequent variants. We propose the adoption of a new, unambiguous naming scheme for CaMKII variants. Finally, we discuss biological implications for CaMKII splice variants. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=153299400 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/ejn.14761 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 15 StartPage: 6780 Subjects: – SubjectFull: Alternative RNA splicing Type: general – SubjectFull: Long-term potentiation Type: general – SubjectFull: Protein kinases Type: general – SubjectFull: Calmodulin Type: general – SubjectFull: Synapses Type: general – SubjectFull: Human genes Type: general Titles: – TitleFull: Functional implications of CaMKII alternative splicing. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Sloutsky, Roman – PersonEntity: Name: NameFull: Stratton, Margaret M. IsPartOfRelationships: – BibEntity: Dates: – D: 15 M: 10 Text: Oct2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 0953816X Numbering: – Type: volume Value: 54 – Type: issue Value: 8 Titles: – TitleFull: European Journal of Neuroscience Type: main |
| ResultId | 1 |
