Increasing trend in the prevalence of alcohol‐sensitive individuals with alcohol use disorder over the past 40 years.
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| Title: | Increasing trend in the prevalence of alcohol‐sensitive individuals with alcohol use disorder over the past 40 years. |
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| Authors: | Ueno, Fumihiko (AUTHOR), Uchida, Hiroyuki (AUTHOR), Kimura, Mitsuru (AUTHOR), Yokoyama, Akira (AUTHOR), Yonemoto, Tomoko (AUTHOR), Itoh, Mitsuru (AUTHOR), Yumoto, Yosuke (AUTHOR), Nakayama, Hideki (AUTHOR), Matsushita, Sachio (AUTHOR) |
| Source: | Psychiatry & Clinical Neurosciences. Jan2022, Vol. 76 Issue 1, p32-33. 2p. 1 Diagram. |
| Subjects: | Alcoholism, Alcohol drinking, Alcoholic beverages, Alcoholism relapse |
| Abstract: | The inactive form of aldehyde dehydrogenase-2 allele ( I ALDH2*2 i (rs671, Glu487Lys)) is present in approximately 40% of the East Asians including Japanese but rarely found in other ethnics.1 I ALDH2*2 i leads to high blood acetaldehyde concentrations which cause various discomforting symptoms; therefore, I ALDH2*2 i careers have been considered unlikely to develop alcohol use disorder (AUD). Increasing trend in the prevalence of alcohol-sensitive individuals with alcohol use disorder over the past 40 years ALDH2, aldehyde dehydrogenase-2; AUD, alcohol use disorder; CI, confidence interval. gl Moreover, we found four cases who were homozygous for I ALDH2*2 i very recently (one (2013), two (2015), and one (2019)), which are theoretically further less likely to develop AUD than those with heterozygotes. [Extracted from the article] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | The inactive form of aldehyde dehydrogenase-2 allele ( I ALDH2*2 i (rs671, Glu487Lys)) is present in approximately 40% of the East Asians including Japanese but rarely found in other ethnics.1 I ALDH2*2 i leads to high blood acetaldehyde concentrations which cause various discomforting symptoms; therefore, I ALDH2*2 i careers have been considered unlikely to develop alcohol use disorder (AUD). Increasing trend in the prevalence of alcohol-sensitive individuals with alcohol use disorder over the past 40 years ALDH2, aldehyde dehydrogenase-2; AUD, alcohol use disorder; CI, confidence interval. gl Moreover, we found four cases who were homozygous for I ALDH2*2 i very recently (one (2013), two (2015), and one (2019)), which are theoretically further less likely to develop AUD than those with heterozygotes. [Extracted from the article] |
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| ISSN: | 13231316 |
| DOI: | 10.1111/pcn.13307 |
