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Increasing trend in the prevalence of alcohol‐sensitive individuals with alcohol use disorder over the past 40 years.

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Title: Increasing trend in the prevalence of alcohol‐sensitive individuals with alcohol use disorder over the past 40 years.
Authors: Ueno, Fumihiko (AUTHOR), Uchida, Hiroyuki (AUTHOR), Kimura, Mitsuru (AUTHOR), Yokoyama, Akira (AUTHOR), Yonemoto, Tomoko (AUTHOR), Itoh, Mitsuru (AUTHOR), Yumoto, Yosuke (AUTHOR), Nakayama, Hideki (AUTHOR), Matsushita, Sachio (AUTHOR)
Source: Psychiatry & Clinical Neurosciences. Jan2022, Vol. 76 Issue 1, p32-33. 2p. 1 Diagram.
Subjects: Alcoholism, Alcohol drinking, Alcoholic beverages, Alcoholism relapse
Abstract: The inactive form of aldehyde dehydrogenase-2 allele ( I ALDH2*2 i (rs671, Glu487Lys)) is present in approximately 40% of the East Asians including Japanese but rarely found in other ethnics.1 I ALDH2*2 i leads to high blood acetaldehyde concentrations which cause various discomforting symptoms; therefore, I ALDH2*2 i careers have been considered unlikely to develop alcohol use disorder (AUD). Increasing trend in the prevalence of alcohol-sensitive individuals with alcohol use disorder over the past 40 years ALDH2, aldehyde dehydrogenase-2; AUD, alcohol use disorder; CI, confidence interval. gl Moreover, we found four cases who were homozygous for I ALDH2*2 i very recently (one (2013), two (2015), and one (2019)), which are theoretically further less likely to develop AUD than those with heterozygotes. [Extracted from the article]
Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
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  Data: Increasing trend in the prevalence of alcohol‐sensitive individuals with alcohol use disorder over the past 40 years.
– Name: Author
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  Data: <searchLink fieldCode="AR" term="%22Ueno%2C+Fumihiko%22">Ueno, Fumihiko</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Uchida%2C+Hiroyuki%22">Uchida, Hiroyuki</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kimura%2C+Mitsuru%22">Kimura, Mitsuru</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yokoyama%2C+Akira%22">Yokoyama, Akira</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yonemoto%2C+Tomoko%22">Yonemoto, Tomoko</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Itoh%2C+Mitsuru%22">Itoh, Mitsuru</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yumoto%2C+Yosuke%22">Yumoto, Yosuke</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nakayama%2C+Hideki%22">Nakayama, Hideki</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Matsushita%2C+Sachio%22">Matsushita, Sachio</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Psychiatry+%26+Clinical+Neurosciences%22">Psychiatry & Clinical Neurosciences</searchLink>. Jan2022, Vol. 76 Issue 1, p32-33. 2p. 1 Diagram.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Alcoholism%22">Alcoholism</searchLink><br /><searchLink fieldCode="DE" term="%22Alcohol+drinking%22">Alcohol drinking</searchLink><br /><searchLink fieldCode="DE" term="%22Alcoholic+beverages%22">Alcoholic beverages</searchLink><br /><searchLink fieldCode="DE" term="%22Alcoholism+relapse%22">Alcoholism relapse</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The inactive form of aldehyde dehydrogenase-2 allele ( I ALDH2*2 i (rs671, Glu487Lys)) is present in approximately 40% of the East Asians including Japanese but rarely found in other ethnics.1 I ALDH2*2 i leads to high blood acetaldehyde concentrations which cause various discomforting symptoms; therefore, I ALDH2*2 i careers have been considered unlikely to develop alcohol use disorder (AUD). Increasing trend in the prevalence of alcohol-sensitive individuals with alcohol use disorder over the past 40 years ALDH2, aldehyde dehydrogenase-2; AUD, alcohol use disorder; CI, confidence interval. gl Moreover, we found four cases who were homozygous for I ALDH2*2 i very recently (one (2013), two (2015), and one (2019)), which are theoretically further less likely to develop AUD than those with heterozygotes. [Extracted from the article]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/pcn.13307
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        Text: English
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      – SubjectFull: Alcohol drinking
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      – SubjectFull: Alcoholic beverages
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      – SubjectFull: Alcoholism relapse
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              Text: Jan2022
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              Y: 2022
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