The burden of early life stress on the nociceptive system development and pain responses.
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| Title: | The burden of early life stress on the nociceptive system development and pain responses. |
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| Authors: | Melchior, Meggane (AUTHOR), Kuhn, Pierre (AUTHOR), Poisbeau, Pierrick (AUTHOR), Robinson, Oliver (AUTHOR) |
| Source: | European Journal of Neuroscience. May2022, Vol. 55 Issue 9/10, p2216-2241. 26p. 1 Illustration, 3 Diagrams, 4 Charts. |
| Subjects: | Systems development, Newborn infants, Premature infants, Chronic pain, Psychological stress |
| Abstract: | For a long time, the capacity of the newborn infant to feel pain was denied. Today it is clear that the nociceptive system, even if still immature, is functional enough in the newborn infant to elicit pain responses. Unfortunately, pain is often present in the neonatal period, in particular in the case of premature infants which are subjected to a high number of painful procedures during care. These are accompanied by a variety of environmental stressors, which could impact the maturation of the nociceptive system. Therefore, the question of the long‐term consequences of early life stress is a critical question. Early stressful experience, both painful and non‐painful, can imprint the nociceptive system and induce long‐term alteration in brain function and nociceptive behavior, often leading to an increase sensitivity and higher susceptibility to chronic pain. Different animal models have been developed to understand the mechanisms underlying the long‐term effects of different early life stressful procedures, including pain and maternal separation. This review will focus on the clinical and preclinical data about early life stress and its consequence on the nociceptive system. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | For a long time, the capacity of the newborn infant to feel pain was denied. Today it is clear that the nociceptive system, even if still immature, is functional enough in the newborn infant to elicit pain responses. Unfortunately, pain is often present in the neonatal period, in particular in the case of premature infants which are subjected to a high number of painful procedures during care. These are accompanied by a variety of environmental stressors, which could impact the maturation of the nociceptive system. Therefore, the question of the long‐term consequences of early life stress is a critical question. Early stressful experience, both painful and non‐painful, can imprint the nociceptive system and induce long‐term alteration in brain function and nociceptive behavior, often leading to an increase sensitivity and higher susceptibility to chronic pain. Different animal models have been developed to understand the mechanisms underlying the long‐term effects of different early life stressful procedures, including pain and maternal separation. This review will focus on the clinical and preclinical data about early life stress and its consequence on the nociceptive system. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 0953816X |
| DOI: | 10.1111/ejn.15153 |
