Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin.
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| Title: | Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin. |
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| Authors: | Spaan, András N., Neehus, Anna-Lena, Laplantine, Emmanuel, Staels, Frederik, Ogishi, Masato, Seeleuthner, Yoann, Rapaport, Franck, Lacey, Keenan A., Van Nieuwenhove, Erika, Chrabieh, Maya, Hum, David, Migaud, Mélanie, Izmiryan, Araksya, Lorenzo, Lazaro, Kochetkov, Tatiana, Heesterbeek, Dani A. C., Bardoel, Bart W., DuMont, Ashley L., Dobbs, Kerry, Chardonnet, Solenne |
| Source: | Science (pre-March 2025). 6/17/2022, Vol. 376 Issue 6599, p1285-1285. 1p. 1 Color Photograph. |
| Subjects: | Staphylococcus aureus, Pathogenic microorganisms, Health, Immunity, Immunoglobulins |
| Abstract: | The article presents the discussion on Staphylococcus aureus being a bacterial pathogen with a global impact on human health. Topics include individuals carrying S. aureus on the skin and in the nostrils showing minority developing life-threatening staphylococcal disease; and impairing cell-intrinsic immunity to a-toxin owing to OTULIN haploinsufficiency being rescued by a-toxin–neutralizing antibodies. |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | The article presents the discussion on Staphylococcus aureus being a bacterial pathogen with a global impact on human health. Topics include individuals carrying S. aureus on the skin and in the nostrils showing minority developing life-threatening staphylococcal disease; and impairing cell-intrinsic immunity to a-toxin owing to OTULIN haploinsufficiency being rescued by a-toxin–neutralizing antibodies. |
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| ISSN: | 00368075 |
| DOI: | 10.1126/science.abm6380 |
