View in EDS HTML Full Text PDF Full Text

Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin.

Saved in:
Bibliographic Details
Title: Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin.
Authors: Spaan, András N., Neehus, Anna-Lena, Laplantine, Emmanuel, Staels, Frederik, Ogishi, Masato, Seeleuthner, Yoann, Rapaport, Franck, Lacey, Keenan A., Van Nieuwenhove, Erika, Chrabieh, Maya, Hum, David, Migaud, Mélanie, Izmiryan, Araksya, Lorenzo, Lazaro, Kochetkov, Tatiana, Heesterbeek, Dani A. C., Bardoel, Bart W., DuMont, Ashley L., Dobbs, Kerry, Chardonnet, Solenne
Source: Science (pre-March 2025). 6/17/2022, Vol. 376 Issue 6599, p1285-1285. 1p. 1 Color Photograph.
Subjects: Staphylococcus aureus, Pathogenic microorganisms, Health, Immunity, Immunoglobulins
Abstract: The article presents the discussion on Staphylococcus aureus being a bacterial pathogen with a global impact on human health. Topics include individuals carrying S. aureus on the skin and in the nostrils showing minority developing life-threatening staphylococcal disease; and impairing cell-intrinsic immunity to a-toxin owing to OTULIN haploinsufficiency being rescued by a-toxin–neutralizing antibodies.
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 157480141
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Spaan%2C+András+N%2E%22">Spaan, András N.</searchLink><br /><searchLink fieldCode="AR" term="%22Neehus%2C+Anna-Lena%22">Neehus, Anna-Lena</searchLink><br /><searchLink fieldCode="AR" term="%22Laplantine%2C+Emmanuel%22">Laplantine, Emmanuel</searchLink><br /><searchLink fieldCode="AR" term="%22Staels%2C+Frederik%22">Staels, Frederik</searchLink><br /><searchLink fieldCode="AR" term="%22Ogishi%2C+Masato%22">Ogishi, Masato</searchLink><br /><searchLink fieldCode="AR" term="%22Seeleuthner%2C+Yoann%22">Seeleuthner, Yoann</searchLink><br /><searchLink fieldCode="AR" term="%22Rapaport%2C+Franck%22">Rapaport, Franck</searchLink><br /><searchLink fieldCode="AR" term="%22Lacey%2C+Keenan+A%2E%22">Lacey, Keenan A.</searchLink><br /><searchLink fieldCode="AR" term="%22Van+Nieuwenhove%2C+Erika%22">Van Nieuwenhove, Erika</searchLink><br /><searchLink fieldCode="AR" term="%22Chrabieh%2C+Maya%22">Chrabieh, Maya</searchLink><br /><searchLink fieldCode="AR" term="%22Hum%2C+David%22">Hum, David</searchLink><br /><searchLink fieldCode="AR" term="%22Migaud%2C+Mélanie%22">Migaud, Mélanie</searchLink><br /><searchLink fieldCode="AR" term="%22Izmiryan%2C+Araksya%22">Izmiryan, Araksya</searchLink><br /><searchLink fieldCode="AR" term="%22Lorenzo%2C+Lazaro%22">Lorenzo, Lazaro</searchLink><br /><searchLink fieldCode="AR" term="%22Kochetkov%2C+Tatiana%22">Kochetkov, Tatiana</searchLink><br /><searchLink fieldCode="AR" term="%22Heesterbeek%2C+Dani+A%2E+C%2E%22">Heesterbeek, Dani A. C.</searchLink><br /><searchLink fieldCode="AR" term="%22Bardoel%2C+Bart+W%2E%22">Bardoel, Bart W.</searchLink><br /><searchLink fieldCode="AR" term="%22DuMont%2C+Ashley+L%2E%22">DuMont, Ashley L.</searchLink><br /><searchLink fieldCode="AR" term="%22Dobbs%2C+Kerry%22">Dobbs, Kerry</searchLink><br /><searchLink fieldCode="AR" term="%22Chardonnet%2C+Solenne%22">Chardonnet, Solenne</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 6/17/2022, Vol. 376 Issue 6599, p1285-1285. 1p. 1 Color Photograph.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Staphylococcus+aureus%22">Staphylococcus aureus</searchLink><br /><searchLink fieldCode="DE" term="%22Pathogenic+microorganisms%22">Pathogenic microorganisms</searchLink><br /><searchLink fieldCode="DE" term="%22Health%22">Health</searchLink><br /><searchLink fieldCode="DE" term="%22Immunity%22">Immunity</searchLink><br /><searchLink fieldCode="DE" term="%22Immunoglobulins%22">Immunoglobulins</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The article presents the discussion on Staphylococcus aureus being a bacterial pathogen with a global impact on human health. Topics include individuals carrying S. aureus on the skin and in the nostrils showing minority developing life-threatening staphylococcal disease; and impairing cell-intrinsic immunity to a-toxin owing to OTULIN haploinsufficiency being rescued by a-toxin–neutralizing antibodies.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=157480141
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1126/science.abm6380
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 1
        StartPage: 1285
    Subjects:
      – SubjectFull: Staphylococcus aureus
        Type: general
      – SubjectFull: Pathogenic microorganisms
        Type: general
      – SubjectFull: Health
        Type: general
      – SubjectFull: Immunity
        Type: general
      – SubjectFull: Immunoglobulins
        Type: general
    Titles:
      – TitleFull: Human OTULIN haploinsufficiency impairs cell-intrinsic immunity to staphylococcal α-toxin.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Spaan, András N.
      – PersonEntity:
          Name:
            NameFull: Neehus, Anna-Lena
      – PersonEntity:
          Name:
            NameFull: Laplantine, Emmanuel
      – PersonEntity:
          Name:
            NameFull: Staels, Frederik
      – PersonEntity:
          Name:
            NameFull: Ogishi, Masato
      – PersonEntity:
          Name:
            NameFull: Seeleuthner, Yoann
      – PersonEntity:
          Name:
            NameFull: Rapaport, Franck
      – PersonEntity:
          Name:
            NameFull: Lacey, Keenan A.
      – PersonEntity:
          Name:
            NameFull: Van Nieuwenhove, Erika
      – PersonEntity:
          Name:
            NameFull: Chrabieh, Maya
      – PersonEntity:
          Name:
            NameFull: Hum, David
      – PersonEntity:
          Name:
            NameFull: Migaud, Mélanie
      – PersonEntity:
          Name:
            NameFull: Izmiryan, Araksya
      – PersonEntity:
          Name:
            NameFull: Lorenzo, Lazaro
      – PersonEntity:
          Name:
            NameFull: Kochetkov, Tatiana
      – PersonEntity:
          Name:
            NameFull: Heesterbeek, Dani A. C.
      – PersonEntity:
          Name:
            NameFull: Bardoel, Bart W.
      – PersonEntity:
          Name:
            NameFull: DuMont, Ashley L.
      – PersonEntity:
          Name:
            NameFull: Dobbs, Kerry
      – PersonEntity:
          Name:
            NameFull: Chardonnet, Solenne
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 17
              M: 06
              Text: 6/17/2022
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-print
              Value: 00368075
          Numbering:
            – Type: volume
              Value: 376
            – Type: issue
              Value: 6599
          Titles:
            – TitleFull: Science (pre-March 2025)
              Type: main
ResultId 1