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Real-time quaking-induced conversion assay is accurate for Lewy body diseases: a meta-analysis.

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Title: Real-time quaking-induced conversion assay is accurate for Lewy body diseases: a meta-analysis.
Authors: Wang, Yashan (AUTHOR), Hu, Jiayi (AUTHOR), Chen, Xiaofei (AUTHOR), Wang, Song (AUTHOR), Zhang, Chenyang (AUTHOR), Hu, Junjun (AUTHOR), Guo, Dingjie (AUTHOR), Liu, Xin (AUTHOR)
Source: Neurological Sciences. Jul2022, Vol. 43 Issue 7, p4125-4132. 8p. 1 Diagram, 2 Charts, 3 Graphs.
Subjects: Receiver operating characteristic curves, Prion diseases, Alpha-synuclein, Lewy body dementia, Neurons, Meta-analysis, Sensitivity & specificity (Statistics), Biological assay
Abstract: Objective: Real-time quaking-induced conversion (RT-QuIC) is a novel in vitro acellular seed amplification analysis and has been widely used to detect prion diseases. Due to the similar mechanism of abnormal aggregation of α-synuclein, RT-QuIC has great potential for diagnosing Lewy body diseases. This meta-analysis was performed to evaluate the diagnostic accuracy of RT-QuIC for Lewy body diseases.Methods: This study followed the PRISMA statement. We searched six databases for relevant studies published until February 20, 2022. Meta-analysis was conducted using RevMan 5.3, Stata 17.0, and Meta-Disc 1.4. Subgroup analyses were performed to explore sources of heterogeneity.Results: A total of 16 studies were included in this study. The pooled sensitivity and specificity were 0.91 (95%CI: 0.85-0.94) and 0.95 (95%CI: 0.90-0.97), respectively. The pooled positive and negative likelihood ratios were 17.16 (95% CI: 9.16-32.14) and 0.10 (95% CI: 0.06-0.17), respectively. The pooled diagnostic odds rate and area under the summary receiver operating characteristic curve were 171.16 (95% CI: 66.64-439.62) and 0.97 (95% CI: 0.96-0.99), respectively.Conclusions: This study was the first meta-analysis on RT-QuIC for Lewy body diseases. RT-QuIC is a reliable and accurate method to diagnose Lewy body diseases. [ABSTRACT FROM AUTHOR]
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Database: Psychology and Behavioral Sciences Collection
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Abstract:<bold>Objective: </bold>Real-time quaking-induced conversion (RT-QuIC) is a novel in vitro acellular seed amplification analysis and has been widely used to detect prion diseases. Due to the similar mechanism of abnormal aggregation of α-synuclein, RT-QuIC has great potential for diagnosing Lewy body diseases. This meta-analysis was performed to evaluate the diagnostic accuracy of RT-QuIC for Lewy body diseases.<bold>Methods: </bold>This study followed the PRISMA statement. We searched six databases for relevant studies published until February 20, 2022. Meta-analysis was conducted using RevMan 5.3, Stata 17.0, and Meta-Disc 1.4. Subgroup analyses were performed to explore sources of heterogeneity.<bold>Results: </bold>A total of 16 studies were included in this study. The pooled sensitivity and specificity were 0.91 (95%CI: 0.85-0.94) and 0.95 (95%CI: 0.90-0.97), respectively. The pooled positive and negative likelihood ratios were 17.16 (95% CI: 9.16-32.14) and 0.10 (95% CI: 0.06-0.17), respectively. The pooled diagnostic odds rate and area under the summary receiver operating characteristic curve were 171.16 (95% CI: 66.64-439.62) and 0.97 (95% CI: 0.96-0.99), respectively.<bold>Conclusions: </bold>This study was the first meta-analysis on RT-QuIC for Lewy body diseases. RT-QuIC is a reliable and accurate method to diagnose Lewy body diseases. [ABSTRACT FROM AUTHOR]
ISSN:15901874
DOI:10.1007/s10072-022-06014-x