Post-mortem gene expression of calcium channels Cav1.2 and Cav1.3 in schizophrenia.
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| Title: | Post-mortem gene expression of calcium channels Cav1.2 and Cav1.3 in schizophrenia. |
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| Authors: | Schmitt, Andrea (AUTHOR), Uhrig, Stefanie (AUTHOR), Spanagel, Rainer (AUTHOR), von Wilmsdorff, Martina (AUTHOR), Kalman, Janos L. (AUTHOR), Schneider-Axmann, Thomas (AUTHOR), Falkai, Peter (AUTHOR), Hansson, Anita C. (AUTHOR) |
| Source: | European Archives of Psychiatry & Clinical Neuroscience. Oct2022, Vol. 272 Issue 7, p1135-1137. 3p. 1 Graph. |
| Subjects: | Gene expression, Calcium channels, Schizophrenia, Social defeat, Genetic variation |
| Abstract: | Schizophrenia is a severe neuropsychiatric disorder with a heritability of 60-80%, and is associated with an unfavorable outcome including cognitive impairment, in more than half of the patients. Therefore, in this study, we investigated the mRNA expression of the two isoforms Cav1.2 and Cav1.3 in post-mortem prefrontal, temporal, cerebellar and caudate brain regions in schizophrenia patients compared to healthy controls. In contrast to our results in adult patients, in induced human neurons from healthy volunteers with the CACNA1C homozygous risk genotype SNP rs1006737, an increased mRNA expression of Cav1.2 has been demonstrated compared to the non-risk genotype [[6]]. [Extracted from the article] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Schizophrenia is a severe neuropsychiatric disorder with a heritability of 60-80%, and is associated with an unfavorable outcome including cognitive impairment, in more than half of the patients. Therefore, in this study, we investigated the mRNA expression of the two isoforms Cav1.2 and Cav1.3 in post-mortem prefrontal, temporal, cerebellar and caudate brain regions in schizophrenia patients compared to healthy controls. In contrast to our results in adult patients, in induced human neurons from healthy volunteers with the CACNA1C homozygous risk genotype SNP rs1006737, an increased mRNA expression of Cav1.2 has been demonstrated compared to the non-risk genotype [[6]]. [Extracted from the article] |
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| ISSN: | 09401334 |
| DOI: | 10.1007/s00406-022-01482-w |
