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Post-mortem gene expression of calcium channels Cav1.2 and Cav1.3 in schizophrenia.

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Title: Post-mortem gene expression of calcium channels Cav1.2 and Cav1.3 in schizophrenia.
Authors: Schmitt, Andrea (AUTHOR), Uhrig, Stefanie (AUTHOR), Spanagel, Rainer (AUTHOR), von Wilmsdorff, Martina (AUTHOR), Kalman, Janos L. (AUTHOR), Schneider-Axmann, Thomas (AUTHOR), Falkai, Peter (AUTHOR), Hansson, Anita C. (AUTHOR)
Source: European Archives of Psychiatry & Clinical Neuroscience. Oct2022, Vol. 272 Issue 7, p1135-1137. 3p. 1 Graph.
Subjects: Gene expression, Calcium channels, Schizophrenia, Social defeat, Genetic variation
Abstract: Schizophrenia is a severe neuropsychiatric disorder with a heritability of 60-80%, and is associated with an unfavorable outcome including cognitive impairment, in more than half of the patients. Therefore, in this study, we investigated the mRNA expression of the two isoforms Cav1.2 and Cav1.3 in post-mortem prefrontal, temporal, cerebellar and caudate brain regions in schizophrenia patients compared to healthy controls. In contrast to our results in adult patients, in induced human neurons from healthy volunteers with the CACNA1C homozygous risk genotype SNP rs1006737, an increased mRNA expression of Cav1.2 has been demonstrated compared to the non-risk genotype [[6]]. [Extracted from the article]
Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Post-mortem gene expression of calcium channels Cav1.2 and Cav1.3 in schizophrenia.
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  Data: <searchLink fieldCode="AR" term="%22Schmitt%2C+Andrea%22">Schmitt, Andrea</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Uhrig%2C+Stefanie%22">Uhrig, Stefanie</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Spanagel%2C+Rainer%22">Spanagel, Rainer</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22von+Wilmsdorff%2C+Martina%22">von Wilmsdorff, Martina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kalman%2C+Janos+L%2E%22">Kalman, Janos L.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Schneider-Axmann%2C+Thomas%22">Schneider-Axmann, Thomas</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Falkai%2C+Peter%22">Falkai, Peter</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hansson%2C+Anita+C%2E%22">Hansson, Anita C.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Oct2022, Vol. 272 Issue 7, p1135-1137. 3p. 1 Graph.
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  Data: <searchLink fieldCode="DE" term="%22Gene+expression%22">Gene expression</searchLink><br /><searchLink fieldCode="DE" term="%22Calcium+channels%22">Calcium channels</searchLink><br /><searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Social+defeat%22">Social defeat</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+variation%22">Genetic variation</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Schizophrenia is a severe neuropsychiatric disorder with a heritability of 60-80%, and is associated with an unfavorable outcome including cognitive impairment, in more than half of the patients. Therefore, in this study, we investigated the mRNA expression of the two isoforms Cav1.2 and Cav1.3 in post-mortem prefrontal, temporal, cerebellar and caudate brain regions in schizophrenia patients compared to healthy controls. In contrast to our results in adult patients, in induced human neurons from healthy volunteers with the CACNA1C homozygous risk genotype SNP rs1006737, an increased mRNA expression of Cav1.2 has been demonstrated compared to the non-risk genotype [[6]]. [Extracted from the article]
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  Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s00406-022-01482-w
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      – Code: eng
        Text: English
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              Text: Oct2022
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