Bibliographic Details
| Title: |
Spouse bereavement and brain pathologies: A propensity score matching study. |
| Alternate Title: |
配偶者との死別と脳の病理：傾向スコアマッチング研究. |
| Authors: |
Jee Wook Kim, Min Soo Byun, Jun Ho Lee, Dahyun Yi, Min Jung Kim, Gijung Jung, Jun-Young Lee, Yun-Sang Lee, Yu Kyeong Kim, Koung Mi Kang, Chul-Ho Sohn, Dong Young Lee |
| Source: |
Psychiatry & Clinical Neurosciences. Oct2022, Vol. 76 Issue 10, p490-504. 15p. |
| Subjects: |
Propensity score matching, Brain diseases, Bereavement, Magnetic resonance imaging, Older people |
| Geographic Terms: |
Pittsburgh (Pa.) |
| Abstract (English): |
Aim: Spouse bereavement is one of life’s greatest stresses and has been suggested to trigger or accelerate cognitive decline and dementia. However, little information is available about the potential brain pathologies underlying the association between spouse bereavement and cognitive decline. We aimed to investigate that lifetime spouse bereavement is associated with in vivo human brain pathologies underlying cognitive decline. Methods: A total of 319 ever-married older adults between the ages of 61 and 90 years underwent comprehensive clinical assessments and multimodal brain imaging including [ 11C] Pittsburgh compound B-positron emission tomography (PET), AV-1451 PET, [18F] fluorodeoxyglucose-PET, and magnetic resonance imaging. Participants were classified as experiencing no spouse bereavement or spouse bereavement, and comparisons using propensity score matching (59 cases and 59 controls) were performed. Results: Spouse bereavement was significantly associated with higher cerebral white matter hyperintensity (WMH) volume compared with no spouse bereavement. Interaction and subsequent subgroup analyses showed that spouse bereavement was significantly associated with higher WMH in the older (>75 years) subgroup and among those with no-or low-skill occupations. In addition, spouse bereavement at 60 years or older affects WMH volume compared with no spouse bereavement, whereas spouse bereavement at younger than 60 years did not. No group differences were observed in other brain pathologies between spouse bereavement categories. Conclusions: The findings suggest that the spouse bereavement may contribute to dementia or cognitive decline by increasing cerebrovascular injury, particularly in older individuals and those with no- or low-skill occupations. [ABSTRACT FROM AUTHOR] |
| Abstract (Japanese): |
【目的】配偶者との死別は、生涯で最大のストレスの 1 つであり、認知機能低下及び認知症を誘発する、または加速 させることが示唆されている. しかし、配偶者との死別と認知機能低下との関連の基盤となり得る脳の病理 については、情報がほとんどない. 我々の目的は、生涯の配偶者死別と、認知機能低下の原因となる in vivo のヒト脳病理変化との関連について調べることであった. 【方法】61 歳～90 歳の既婚高齢者計 319 名を対象に、包括的臨床評価と、[11C] ピッツバーグ化合物 B-陽電子放出 断層撮影(PET)、AV-1451 PET、[18F]フルオロデオキシグルコース-PET、及び磁気共鳴画像法を含むマル チモーダル脳イメージング検査を実施した. 参加者を、配偶者との死別を経験していない者と配偶者との死 別を経験した者に分け、傾向スコアマッチングを使用して比較した(症例 59 名と対照 59 名). 【結果】配偶者との死別経験は、配偶者との死別未経験と比べて脳白質高信号域(WMH)容積高値と有意に関連して いた. 相互作用解析後にサブグループ解析を実施したところ、高齢(>75 歳)サブグループおよび非高度技能 職の人において、配偶者との死別は高 WMH と有意な関連があった. また、60 歳以上での配偶者との死別 経験は、配偶者との死別未経験と比べて WMH 容積に影響を及ぼすが、60 歳未満での配偶者との死別経験 は影響を及ぼさなかった. 配偶者との死別区分に基づく群の間で、他の脳病理変化に差は認められなかった. 【結論】本研究の結果は、より高齢の人および非高度技能職の人では特に、配偶者との死別が、脳血管障害を増大さ せることによって、認知症又は認知機能低下に寄与する可能性があることを示唆する. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
