An update on hypertension.
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| Title: | An update on hypertension. |
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| Authors: | Mrowka, Ralf (AUTHOR) |
| Source: | Acta Physiologica. Mar2023, Vol. 237 Issue 3, p1-4. 4p. |
| Subjects: | Hypertension, Heart failure, Salt-free diet, Comparative physiology, Carrier proteins, Hyperkalemia, Low-potassium diet, Parasympathetic nervous system, Allergy desensitization |
| Abstract: | Arterial hypertension is a serious medical condition that significantly increases the risks of heart, brain, kidney, and other diseases affecting 1.28 billion adults worldwide. The authors employed an animal model with wild-type (Floxed) and CD-specific deletion of renin (CD renin KO) mice. In animals, immunofluorescence analysis of renal sections from mice after 5 days of acute pyelonephritis revealed apical plasma membrane targeting of AQP2 and pS256-AQP2 in inner medullary collecting ducts. CD renin KO mice had blunted HK-induced intrarenal renin response and developed impaired kaliuresis and elevated plasma potassium level. [Extracted from the article] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Arterial hypertension is a serious medical condition that significantly increases the risks of heart, brain, kidney, and other diseases affecting 1.28 billion adults worldwide. The authors employed an animal model with wild-type (Floxed) and CD-specific deletion of renin (CD renin KO) mice. In animals, immunofluorescence analysis of renal sections from mice after 5 days of acute pyelonephritis revealed apical plasma membrane targeting of AQP2 and pS256-AQP2 in inner medullary collecting ducts. CD renin KO mice had blunted HK-induced intrarenal renin response and developed impaired kaliuresis and elevated plasma potassium level. [Extracted from the article] |
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| ISSN: | 17481708 |
| DOI: | 10.1111/apha.13942 |
