Impulsivity in amphetamine use disorder: Examination of sex differences.
Saved in:
| Title: | Impulsivity in amphetamine use disorder: Examination of sex differences. |
|---|---|
| Authors: | Stewart, Jennifer L., Burrows, Kaiping, Davis, Chrysantha B., Wilhelm, Ricardo A., McNaughton, Breanna A., Kuplicki, Rayus, Paulus, Martin P., Khalsa, Sahib S., White, Evan J. |
| Source: | Addiction. Sep2023, Vol. 118 Issue 9, p1787-1800. 14p. 4 Diagrams, 4 Charts, 2 Graphs. |
| Subjects: | Human reproduction, Substance abuse, Impulsive personality, Cross-sectional method, Magnetic resonance imaging, Amphetamines, Insular cortex, Research funding, Amygdaloid body |
| Abstract: | Aims: This study aimed to test whether there are sex differences in the relationship between impulsivity and amphetamine use disorder (AMP). Design: A naturalistic cross‐sectional design was used. Setting: The Tulsa 1000 study was held in Tulsa, OK, USA. Participants: There were two groups in this study: AMP+ (29F, 20M) and AMP– (57F, 33M). Measurements This project focuses on data related to impulsivity: UPPS‐P impulsive behavior scale and a stop signal task (SST) during functional magnetic resonance imaging (fMRI) recording. Group, sex and their interaction were compared for UPPS‐P ratings and SST fMRI and behavioral responses. Findings AMP+ reported higher UPPS‐P positive and negative urgency scores (Ps < 0.001; r = 0.56 and 0.51) and displayed greater bilateral insula and amygdala responses across correct SST trials (Ps < 0.001, g range = 0.57–0.81) than AMP–. fMRI results indicated that AMP+ exhibited larger right anterior/middle insula, amygdala and nucleus accumbens signals during successful difficult stop trials than AMP– (Ps < 0.01; g = 0.63, 0.54 and 0.44, respectively). Crucially, two group × sex effects emerged: (a) within females, AMP+ reported larger UPPS‐P lack of premeditation scores than AMP– (P < 0.001, r = 0.51), and (b) within males, AMP+ showed greater left middle insula signals than AMP– across correct SST trials (P = 0.01, g = 0.78). Conclusions: Both female and male amphetamine users appear to be characterized by rash action in the presence of positive and negative mood states as well as heightened recruitment of right hemisphere regions during behavioral inhibition. In contrast, planning ahead may be particularly difficult for female amphetamine users, whereas male amphetamine users may need to recruit additional left hemisphere resources during inhibitory processing. [ABSTRACT FROM AUTHOR] |
| Copyright of Addiction is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
|
Full text is not displayed to guests.
Login for full access.
|
|
| Abstract: | Aims: This study aimed to test whether there are sex differences in the relationship between impulsivity and amphetamine use disorder (AMP). Design: A naturalistic cross‐sectional design was used. Setting: The Tulsa 1000 study was held in Tulsa, OK, USA. Participants: There were two groups in this study: AMP+ (29F, 20M) and AMP– (57F, 33M). Measurements This project focuses on data related to impulsivity: UPPS‐P impulsive behavior scale and a stop signal task (SST) during functional magnetic resonance imaging (fMRI) recording. Group, sex and their interaction were compared for UPPS‐P ratings and SST fMRI and behavioral responses. Findings AMP+ reported higher UPPS‐P positive and negative urgency scores (Ps < 0.001; r = 0.56 and 0.51) and displayed greater bilateral insula and amygdala responses across correct SST trials (Ps < 0.001, g range = 0.57–0.81) than AMP–. fMRI results indicated that AMP+ exhibited larger right anterior/middle insula, amygdala and nucleus accumbens signals during successful difficult stop trials than AMP– (Ps < 0.01; g = 0.63, 0.54 and 0.44, respectively). Crucially, two group × sex effects emerged: (a) within females, AMP+ reported larger UPPS‐P lack of premeditation scores than AMP– (P < 0.001, r = 0.51), and (b) within males, AMP+ showed greater left middle insula signals than AMP– across correct SST trials (P = 0.01, g = 0.78). Conclusions: Both female and male amphetamine users appear to be characterized by rash action in the presence of positive and negative mood states as well as heightened recruitment of right hemisphere regions during behavioral inhibition. In contrast, planning ahead may be particularly difficult for female amphetamine users, whereas male amphetamine users may need to recruit additional left hemisphere resources during inhibitory processing. [ABSTRACT FROM AUTHOR] |
|---|---|
| ISSN: | 09652140 |
| DOI: | 10.1111/add.16225 |
