Clinical usability of the Story-Based Empathy Task (SET) in non-demented ALS patients.
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| Title: | Clinical usability of the Story-Based Empathy Task (SET) in non-demented ALS patients. |
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| Authors: | Aiello, Edoardo Nicolò (AUTHOR), Solca, Federica (AUTHOR), Torre, Silvia (AUTHOR), Colombo, Eleonora (AUTHOR), Maranzano, Alessio (AUTHOR), Olivero, Marco (AUTHOR), Scheveger, Francesco (AUTHOR), Morelli, Claudia (AUTHOR), Doretti, Alberto (AUTHOR), Verde, Federico (AUTHOR), Ferrucci, Roberta (AUTHOR), Barbieri, Sergio (AUTHOR), Mameli, Francesca (AUTHOR), Priori, Alberto (AUTHOR), Silani, Vincenzo (AUTHOR), Ticozzi, Nicola (AUTHOR), Poletti, Barbara (AUTHOR) |
| Source: | Neurological Sciences. Sep2023, Vol. 44 Issue 9, p3181-3187. 7p. 3 Charts. |
| Subjects: | Amyotrophic lateral sclerosis, Empathy, Behavioral assessment, Causal inference, Wechsler Adult Intelligence Scale |
| Abstract: | Background: This study aimed at assessing the clinical usability of the Story-Based Empathy Task (SET) in non-demented amyotrophic lateral sclerosis (ALS) patients. Methods: N = 106 non-demented ALS patients and N = 101 healthy controls (HCs) were administered the SET, which includes three subtests assessing Emotion Attribution (SET-EA), Intention Attribution (SET-IA) and causal inference (SET-CI) — the latter being a control task. Patients also underwent the Reading the Mind in the Eyes Test (RMET), the Edinburgh Cognitive and Behavioural ALS Screen (ECAS) and a thorough behavioural and motor-functional evaluation. The diagnostics of the SET-EA and -IA were tested against a defective performance on the RMET. The association between SET subtests and cognitive/behavioural outcomes was examined net of demographic and motor-functional confounders. Case-control discrimination was explored for each SET subtest. Results: Demographically adjusted SET-EA and -IA scores accurately detected defective RMET performances at the optimal cutoffs of <3.04 (AUC =.84) and <3.61 (AUC =.88), respectively. By contrast, the SET-CI performed poorly in doing so (AUC =.58). The SET-EA converged with the RMET, as well as with ECAS-Executive and -Memory scores, whilst the SET-IA was unrelated to cognitive measures (including the RMET); the SET-CI was related to the ECAS-Language the ECAS-Executive. SET subscores were unrelated to behavioural outcomes. Only the SET-EA discriminated patients from HCs. Conclusions: The SET as a whole should not be addressed as a social-cognitive measure in this population. At variance, its subtest tapping on emotional processing — i.e., the SET-EA — is recommended for use as an estimate of social-cognitive abilities in non-demented ALS patients. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Background: This study aimed at assessing the clinical usability of the Story-Based Empathy Task (SET) in non-demented amyotrophic lateral sclerosis (ALS) patients. Methods: N = 106 non-demented ALS patients and N = 101 healthy controls (HCs) were administered the SET, which includes three subtests assessing Emotion Attribution (SET-EA), Intention Attribution (SET-IA) and causal inference (SET-CI) — the latter being a control task. Patients also underwent the Reading the Mind in the Eyes Test (RMET), the Edinburgh Cognitive and Behavioural ALS Screen (ECAS) and a thorough behavioural and motor-functional evaluation. The diagnostics of the SET-EA and -IA were tested against a defective performance on the RMET. The association between SET subtests and cognitive/behavioural outcomes was examined net of demographic and motor-functional confounders. Case-control discrimination was explored for each SET subtest. Results: Demographically adjusted SET-EA and -IA scores accurately detected defective RMET performances at the optimal cutoffs of <3.04 (AUC =.84) and <3.61 (AUC =.88), respectively. By contrast, the SET-CI performed poorly in doing so (AUC =.58). The SET-EA converged with the RMET, as well as with ECAS-Executive and -Memory scores, whilst the SET-IA was unrelated to cognitive measures (including the RMET); the SET-CI was related to the ECAS-Language the ECAS-Executive. SET subscores were unrelated to behavioural outcomes. Only the SET-EA discriminated patients from HCs. Conclusions: The SET as a whole should not be addressed as a social-cognitive measure in this population. At variance, its subtest tapping on emotional processing — i.e., the SET-EA — is recommended for use as an estimate of social-cognitive abilities in non-demented ALS patients. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 15901874 |
| DOI: | 10.1007/s10072-023-06791-z |
