PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection.
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| Title: | PIM1 controls GBP1 activity to limit self-damage and to guard against pathogen infection. |
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| Authors: | Fisch, Daniel, Pfleiderer, Moritz M., Anastasakou, Eleni, Mackie, Gillian M., Wendt, Fabian, Xiangyang Liu, Clough, Barbara, Lara-Reyna, Samuel, Encheva, Vesela, Snijders, Ambrosius P., Bando, Hironori, Yamamoto, Masahiro, Beggs, Andrew D., Mercer, Jason, Shenoy, Avinash R., Wollscheid, Bernd, Maslowski, Kendle M., Galej, Wojtek P., Frickel, Eva-Maria |
| Source: | Science (pre-March 2025). 10/6/2023, Vol. 382 Issue 6666, p67-67. 1p. 1 Diagram. |
| Subjects: | Apoptosis, Cell morphology |
| Abstract: | The article focuses on how cells protect themselves from self-damage caused by interferon-stimulated genes (ISGs), specifically guanylate-binding proteins (GBPs), in response to interferon-g (IFN-g) stimulation, and how the kinase PIM1 controls GBP1 activity to prevent cellular damage while maintaining its antimicrobial function in human macrophages. |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | The article focuses on how cells protect themselves from self-damage caused by interferon-stimulated genes (ISGs), specifically guanylate-binding proteins (GBPs), in response to interferon-g (IFN-g) stimulation, and how the kinase PIM1 controls GBP1 activity to prevent cellular damage while maintaining its antimicrobial function in human macrophages. |
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| ISSN: | 00368075 |
| DOI: | 10.1126/science.adg2253 |
