Health-related quality of life in Chinese SLE patients: evidence from 1568 SLE patients and 2610 healthy controls.
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| Title: | Health-related quality of life in Chinese SLE patients: evidence from 1568 SLE patients and 2610 healthy controls. |
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| Authors: | Wang, Yu-Hua (AUTHOR), Sun, Hong-Yu (AUTHOR), Liu, Yu-Qi (AUTHOR), Gong, Xing-Yu (AUTHOR), Xu, Ying (AUTHOR), Zong, Qi-Qun (AUTHOR), Yu, Guang-Hui (AUTHOR), Hu, Wan-Qin (AUTHOR), Zhai, Chun-Xia (AUTHOR), Wang, Lin-Lin (AUTHOR), Yan, Zi-Ye (AUTHOR), Zhang, Ting-Yu (AUTHOR), Cai, Jing (AUTHOR), Li, Mu (AUTHOR), Chen, Yang-Fan (AUTHOR), Wang, Fang (AUTHOR), Zou, Yan-Feng (AUTHOR) |
| Source: | Quality of Life Research. Jan2024, Vol. 33 Issue 1, p207-218. 12p. |
| Subjects: | Chinese people, Quality of life, Life change events, Systemic lupus erythematosus |
| Geographic Terms: | China |
| Abstract: | Objective: To investigate the effects of systemic lupus erythematosus (SLE) on health-related quality of life (HRQOL), the relationship between disease activity and HRQOL, and potential factors affecting HRQOL in Chinese SLE patients. Methods: This study recruited 1568 patients and 2610 controls to explore the effects of SLE on HRQOL. The association between disease activity and HRQOL, and the influencing factors of HRQOL were determined in 1568 patients. Then, we prospectively followed 1096 patients to explore the association between reduced disease activity and improved HRQOL, and the influencing factors of improved HRQOL. The Short-Form 36 (SF-36) and SLE disease activity index (SLEDAI) were used to evaluate HRQOL and disease activity. Results: Chinese SLE patients had lower HRQOL than controls in all domains (P < 0.001), especially in role-physical (RP) and role-emotional (RE). Compared with SLE patients from outside China, the HRQOL of Chinese patients appeared to be higher in mental component summary (MCS) but lower in RP and RE. SLEDAI was negatively correlated with HRQOL, which was validated using the results of a follow-up study, where SLEDAI reduction was positively associated with HRQOL improvements (P < 0.05). Furthermore, personality, life nervous and experiences of adverse life events may influence HRQOL and HRQOL improvements. Conclusion: SLE significantly affected the HRQOL of Chinese patients, especially in RP and RE. Disease activity was negatively correlated with HRQOL. We also found for the first time some factors affecting HRQOL, which can be regarded as the basis for improving the HRQOL of SLE patients. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Objective: To investigate the effects of systemic lupus erythematosus (SLE) on health-related quality of life (HRQOL), the relationship between disease activity and HRQOL, and potential factors affecting HRQOL in Chinese SLE patients. Methods: This study recruited 1568 patients and 2610 controls to explore the effects of SLE on HRQOL. The association between disease activity and HRQOL, and the influencing factors of HRQOL were determined in 1568 patients. Then, we prospectively followed 1096 patients to explore the association between reduced disease activity and improved HRQOL, and the influencing factors of improved HRQOL. The Short-Form 36 (SF-36) and SLE disease activity index (SLEDAI) were used to evaluate HRQOL and disease activity. Results: Chinese SLE patients had lower HRQOL than controls in all domains (P < 0.001), especially in role-physical (RP) and role-emotional (RE). Compared with SLE patients from outside China, the HRQOL of Chinese patients appeared to be higher in mental component summary (MCS) but lower in RP and RE. SLEDAI was negatively correlated with HRQOL, which was validated using the results of a follow-up study, where SLEDAI reduction was positively associated with HRQOL improvements (P < 0.05). Furthermore, personality, life nervous and experiences of adverse life events may influence HRQOL and HRQOL improvements. Conclusion: SLE significantly affected the HRQOL of Chinese patients, especially in RP and RE. Disease activity was negatively correlated with HRQOL. We also found for the first time some factors affecting HRQOL, which can be regarded as the basis for improving the HRQOL of SLE patients. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 09629343 |
| DOI: | 10.1007/s11136-023-03516-9 |
