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Efficacy of lamotrigine in migralepsy: a case report.

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Title: Efficacy of lamotrigine in migralepsy: a case report.
Authors: Iabichella, Giacomo (AUTHOR), Autunno, Massimo (AUTHOR), Bertino, Salvatore (AUTHOR), Laganà, Angelina (AUTHOR), Labate, Angelo (AUTHOR)
Source: Neurological Sciences. May2024, Vol. 45 Issue 5, p2383-2386. 4p.
Subjects: Epilepsy, Migraine aura, Lamotrigine, Seizures (Medicine), Neurological disorders, People with epilepsy, Spreading cortical depression
Abstract: This letter discusses the relationship between migraine and epilepsy, specifically a condition called migralepsy. Migralepsy is characterized by a seizure that occurs during or within one hour after a migraine with aura. The letter describes a case of a 22-year-old man who experienced migraines with aura followed by epileptic seizures. The patient initially took topiramate, which reduced the frequency of migraines but did not fully control the seizures. The patient then switched to lamotrigine, which significantly improved both the migraines and seizures. The letter suggests that lamotrigine may be more effective in reducing seizure frequency by targeting the mechanisms underlying cortical spreading depression. Further studies are needed to better understand migralepsy. [Extracted from the article]
Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Efficacy of lamotrigine in migralepsy: a case report.
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  Data: <searchLink fieldCode="AR" term="%22Iabichella%2C+Giacomo%22">Iabichella, Giacomo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Autunno%2C+Massimo%22">Autunno, Massimo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bertino%2C+Salvatore%22">Bertino, Salvatore</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Laganà%2C+Angelina%22">Laganà, Angelina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Labate%2C+Angelo%22">Labate, Angelo</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Neurological+Sciences%22">Neurological Sciences</searchLink>. May2024, Vol. 45 Issue 5, p2383-2386. 4p.
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  Data: <searchLink fieldCode="DE" term="%22Epilepsy%22">Epilepsy</searchLink><br /><searchLink fieldCode="DE" term="%22Migraine+aura%22">Migraine aura</searchLink><br /><searchLink fieldCode="DE" term="%22Lamotrigine%22">Lamotrigine</searchLink><br /><searchLink fieldCode="DE" term="%22Seizures+%28Medicine%29%22">Seizures (Medicine)</searchLink><br /><searchLink fieldCode="DE" term="%22Neurological+disorders%22">Neurological disorders</searchLink><br /><searchLink fieldCode="DE" term="%22People+with+epilepsy%22">People with epilepsy</searchLink><br /><searchLink fieldCode="DE" term="%22Spreading+cortical+depression%22">Spreading cortical depression</searchLink>
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  Label: Abstract
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  Data: This letter discusses the relationship between migraine and epilepsy, specifically a condition called migralepsy. Migralepsy is characterized by a seizure that occurs during or within one hour after a migraine with aura. The letter describes a case of a 22-year-old man who experienced migraines with aura followed by epileptic seizures. The patient initially took topiramate, which reduced the frequency of migraines but did not fully control the seizures. The patient then switched to lamotrigine, which significantly improved both the migraines and seizures. The letter suggests that lamotrigine may be more effective in reducing seizure frequency by targeting the mechanisms underlying cortical spreading depression. Further studies are needed to better understand migralepsy. [Extracted from the article]
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  Group: Ab
  Data: <i>Copyright of Neurological Sciences is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10072-023-07291-w
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      – Code: eng
        Text: English
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        PageCount: 4
        StartPage: 2383
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        Type: general
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      – SubjectFull: Lamotrigine
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      – SubjectFull: Spreading cortical depression
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              Text: May2024
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              Y: 2024
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