Mechanisms of minor pole–mediated spindle bipolarization in human oocytes.
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| Title: | Mechanisms of minor pole–mediated spindle bipolarization in human oocytes. |
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| Authors: | Tianyu Wu, Yuxi Luo, Meiling Zhang, Biaobang Chen, Xingzhu Du, Hao Gu, Siyuan Xie, Zhiqi Pan, Ran Yu, Ruiqi Hai, Xiangli Niu, Guimin Hao, Liping Jin, Juanzi Shi, Xiaoxi Sun, Yanping Kuang, Wen Li, Qing Sang, Lei Wang |
| Source: | Science (pre-March 2025). 8/23/2024, Vol. 385 Issue 6711, p844-844. 1p. 1 Diagram. |
| Subjects: | Ovum, Microtubules, Spindle apparatus, Tubulins, Human beings, Nuclear membranes, Female infertility |
| Abstract: | The article focuses on the mechanisms of spindle bipolarization in human oocytes, revealing that minor poles formed by microtubule coalescence lead to the generation of multipolar intermediates before bipolar spindles are established. Topics include the role of specific proteins like HAUS6, KIF11, and KIF18A in spindle bipolarization, the identification of these proteins' mutations affecting oocyte maturation, and the detailed process of how minor poles contribute to spindle formation. |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | The article focuses on the mechanisms of spindle bipolarization in human oocytes, revealing that minor poles formed by microtubule coalescence lead to the generation of multipolar intermediates before bipolar spindles are established. Topics include the role of specific proteins like HAUS6, KIF11, and KIF18A in spindle bipolarization, the identification of these proteins' mutations affecting oocyte maturation, and the detailed process of how minor poles contribute to spindle formation. |
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| ISSN: | 00368075 |
| DOI: | 10.1126/science.ado1022 |
