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Mechanisms of minor pole–mediated spindle bipolarization in human oocytes.

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Title: Mechanisms of minor pole–mediated spindle bipolarization in human oocytes.
Authors: Tianyu Wu, Yuxi Luo, Meiling Zhang, Biaobang Chen, Xingzhu Du, Hao Gu, Siyuan Xie, Zhiqi Pan, Ran Yu, Ruiqi Hai, Xiangli Niu, Guimin Hao, Liping Jin, Juanzi Shi, Xiaoxi Sun, Yanping Kuang, Wen Li, Qing Sang, Lei Wang
Source: Science (pre-March 2025). 8/23/2024, Vol. 385 Issue 6711, p844-844. 1p. 1 Diagram.
Subjects: Ovum, Microtubules, Spindle apparatus, Tubulins, Human beings, Nuclear membranes, Female infertility
Abstract: The article focuses on the mechanisms of spindle bipolarization in human oocytes, revealing that minor poles formed by microtubule coalescence lead to the generation of multipolar intermediates before bipolar spindles are established. Topics include the role of specific proteins like HAUS6, KIF11, and KIF18A in spindle bipolarization, the identification of these proteins' mutations affecting oocyte maturation, and the detailed process of how minor poles contribute to spindle formation.
Database: Psychology and Behavioral Sciences Collection
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Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 179161958
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Mechanisms of minor pole–mediated spindle bipolarization in human oocytes.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Tianyu+Wu%22">Tianyu Wu</searchLink><br /><searchLink fieldCode="AR" term="%22Yuxi+Luo%22">Yuxi Luo</searchLink><br /><searchLink fieldCode="AR" term="%22Meiling+Zhang%22">Meiling Zhang</searchLink><br /><searchLink fieldCode="AR" term="%22Biaobang+Chen%22">Biaobang Chen</searchLink><br /><searchLink fieldCode="AR" term="%22Xingzhu+Du%22">Xingzhu Du</searchLink><br /><searchLink fieldCode="AR" term="%22Hao+Gu%22">Hao Gu</searchLink><br /><searchLink fieldCode="AR" term="%22Siyuan+Xie%22">Siyuan Xie</searchLink><br /><searchLink fieldCode="AR" term="%22Zhiqi+Pan%22">Zhiqi Pan</searchLink><br /><searchLink fieldCode="AR" term="%22Ran+Yu%22">Ran Yu</searchLink><br /><searchLink fieldCode="AR" term="%22Ruiqi+Hai%22">Ruiqi Hai</searchLink><br /><searchLink fieldCode="AR" term="%22Xiangli+Niu%22">Xiangli Niu</searchLink><br /><searchLink fieldCode="AR" term="%22Guimin+Hao%22">Guimin Hao</searchLink><br /><searchLink fieldCode="AR" term="%22Liping+Jin%22">Liping Jin</searchLink><br /><searchLink fieldCode="AR" term="%22Juanzi+Shi%22">Juanzi Shi</searchLink><br /><searchLink fieldCode="AR" term="%22Xiaoxi+Sun%22">Xiaoxi Sun</searchLink><br /><searchLink fieldCode="AR" term="%22Yanping+Kuang%22">Yanping Kuang</searchLink><br /><searchLink fieldCode="AR" term="%22Wen+Li%22">Wen Li</searchLink><br /><searchLink fieldCode="AR" term="%22Qing+Sang%22">Qing Sang</searchLink><br /><searchLink fieldCode="AR" term="%22Lei+Wang%22">Lei Wang</searchLink>
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  Label: Source
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  Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 8/23/2024, Vol. 385 Issue 6711, p844-844. 1p. 1 Diagram.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Ovum%22">Ovum</searchLink><br /><searchLink fieldCode="DE" term="%22Microtubules%22">Microtubules</searchLink><br /><searchLink fieldCode="DE" term="%22Spindle+apparatus%22">Spindle apparatus</searchLink><br /><searchLink fieldCode="DE" term="%22Tubulins%22">Tubulins</searchLink><br /><searchLink fieldCode="DE" term="%22Human+beings%22">Human beings</searchLink><br /><searchLink fieldCode="DE" term="%22Nuclear+membranes%22">Nuclear membranes</searchLink><br /><searchLink fieldCode="DE" term="%22Female+infertility%22">Female infertility</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The article focuses on the mechanisms of spindle bipolarization in human oocytes, revealing that minor poles formed by microtubule coalescence lead to the generation of multipolar intermediates before bipolar spindles are established. Topics include the role of specific proteins like HAUS6, KIF11, and KIF18A in spindle bipolarization, the identification of these proteins' mutations affecting oocyte maturation, and the detailed process of how minor poles contribute to spindle formation.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=179161958
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      – Type: doi
        Value: 10.1126/science.ado1022
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        Text: English
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        StartPage: 844
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      – SubjectFull: Ovum
        Type: general
      – SubjectFull: Microtubules
        Type: general
      – SubjectFull: Spindle apparatus
        Type: general
      – SubjectFull: Tubulins
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      – SubjectFull: Human beings
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      – SubjectFull: Nuclear membranes
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      – SubjectFull: Female infertility
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      – TitleFull: Mechanisms of minor pole–mediated spindle bipolarization in human oocytes.
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              M: 08
              Text: 8/23/2024
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              Y: 2024
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