Identifying the nature of episodic memory deficits in Major Depressive Disorder using a Real-World What-Where-When task.
Saved in:
| Title: | Identifying the nature of episodic memory deficits in Major Depressive Disorder using a Real-World What-Where-When task. |
|---|---|
| Authors: | Foka, Kyriaki (AUTHOR), Hunt, Hannah (AUTHOR), Constantinescu, Simona (AUTHOR), Choudhury, Tahsina (AUTHOR), Walker, Thomas J. (AUTHOR), Black-Dominique, Amber (AUTHOR), Lai, Daniel (AUTHOR), Bhoopathy, Raja (AUTHOR), Sanderson, Olivia (AUTHOR), Wray, Lauren (AUTHOR), McAllister-Williams, R. Hamish (AUTHOR), Gallagher, Peter (AUTHOR), Smulders, Tom V. (AUTHOR) |
| Source: | Memory. Aug2024, Vol. 32 Issue 7, p924-934. 11p. |
| Subjects: | Task performance, Research funding, Episodic memory, Descriptive statistics, Chi-squared test, Neuropsychological tests, Memory, Mental depression, Memory disorders, Regression analysis |
| Abstract: | Deficits in episodic memory have been reported in various psychiatric conditions, including Major Depressive Disorder (MDD). Many widely used episodic memory tests do not have the ability to distinguish between impaired memory of separate components of a real-life event (e.g., what happened, where it happened and when), and impaired binding of such real-life features. To address this issue, a naturalistic, real-world What-Where-When memory task was employed to assess the nature of episodic memory impairments in MDD. A validation study established that the task is sensitive to age-related episodic memory changes, and that intentional encoding does not invalidate the task. The main study then compared the performance of patients with depression and control participants on the intentionally encoded WWW task. Patients with MDD presented an overall episodic memory impairment arising from deficits in object memory and the ability to bind objects to temporal context. Taken together, our study confirms the episodic memory impairment in MDD, by providing evidence of deficient object memory and reduced ability to bind temporal context to objects in patients. Our naturalistic WWW task presents a promising approach for thorough identification of the nature of episodic memory impairments, under a real-world environment, in various conditions, including MDD. [ABSTRACT FROM AUTHOR] |
| Copyright of Memory is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
|
Full text is not displayed to guests.
Login for full access.
|
|
| Abstract: | Deficits in episodic memory have been reported in various psychiatric conditions, including Major Depressive Disorder (MDD). Many widely used episodic memory tests do not have the ability to distinguish between impaired memory of separate components of a real-life event (e.g., what happened, where it happened and when), and impaired binding of such real-life features. To address this issue, a naturalistic, real-world What-Where-When memory task was employed to assess the nature of episodic memory impairments in MDD. A validation study established that the task is sensitive to age-related episodic memory changes, and that intentional encoding does not invalidate the task. The main study then compared the performance of patients with depression and control participants on the intentionally encoded WWW task. Patients with MDD presented an overall episodic memory impairment arising from deficits in object memory and the ability to bind objects to temporal context. Taken together, our study confirms the episodic memory impairment in MDD, by providing evidence of deficient object memory and reduced ability to bind temporal context to objects in patients. Our naturalistic WWW task presents a promising approach for thorough identification of the nature of episodic memory impairments, under a real-world environment, in various conditions, including MDD. [ABSTRACT FROM AUTHOR] |
|---|---|
| ISSN: | 09658211 |
| DOI: | 10.1080/09658211.2024.2371110 |
