Inflammation‐induced fever depends on prostaglandin E2 production by brain endothelial cells and EP3 receptors in the median preoptic nucleus of the hypothalamus.
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| Title: | Inflammation‐induced fever depends on prostaglandin E2 production by brain endothelial cells and EP3 receptors in the median preoptic nucleus of the hypothalamus. |
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| Authors: | Blomqvist, Anders (AUTHOR) |
| Source: | Acta Physiologica. Dec2024, Vol. 240 Issue 12, p1-3. 3p. |
| Subjects: | RNA interference, Cell receptors, Small interfering RNA, Weight loss, Gene expression, Prostaglandin receptors |
| Abstract: | The article in Acta Physiologica discusses the critical role of prostaglandin E2 (PGE2) production in brain endothelial cells in generating fever, emphasizing its importance over other mechanisms. The study highlights that PGE2 synthesis and its binding to EP3 receptors in the median preoptic nucleus of the hypothalamus are essential for fever to occur. While the involvement of microglial cells in fever is debated, the evidence suggests that PGE2 synthesis by brain endothelial cells is a crucial step in the fever response. The findings caution against overinterpreting the role of microglia in fever and underscore the significance of PGE2 synthesis by brain endothelial cells in the process. [Extracted from the article] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | The article in Acta Physiologica discusses the critical role of prostaglandin E2 (PGE2) production in brain endothelial cells in generating fever, emphasizing its importance over other mechanisms. The study highlights that PGE2 synthesis and its binding to EP3 receptors in the median preoptic nucleus of the hypothalamus are essential for fever to occur. While the involvement of microglial cells in fever is debated, the evidence suggests that PGE2 synthesis by brain endothelial cells is a crucial step in the fever response. The findings caution against overinterpreting the role of microglia in fever and underscore the significance of PGE2 synthesis by brain endothelial cells in the process. [Extracted from the article] |
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| ISSN: | 17481708 |
| DOI: | 10.1111/apha.14238 |
