Inflammation‐induced fever depends on prostaglandin E2 production by brain endothelial cells and EP3 receptors in the median preoptic nucleus of the hypothalamus.
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| Title: | Inflammation‐induced fever depends on prostaglandin E2 production by brain endothelial cells and EP3 receptors in the median preoptic nucleus of the hypothalamus. |
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| Authors: | Blomqvist, Anders (AUTHOR) |
| Source: | Acta Physiologica. Dec2024, Vol. 240 Issue 12, p1-3. 3p. |
| Subjects: | RNA interference, Cell receptors, Small interfering RNA, Weight loss, Gene expression, Prostaglandin receptors |
| Abstract: | The article in Acta Physiologica discusses the critical role of prostaglandin E2 (PGE2) production in brain endothelial cells in generating fever, emphasizing its importance over other mechanisms. The study highlights that PGE2 synthesis and its binding to EP3 receptors in the median preoptic nucleus of the hypothalamus are essential for fever to occur. While the involvement of microglial cells in fever is debated, the evidence suggests that PGE2 synthesis by brain endothelial cells is a crucial step in the fever response. The findings caution against overinterpreting the role of microglia in fever and underscore the significance of PGE2 synthesis by brain endothelial cells in the process. [Extracted from the article] |
| Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 180775567 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Inflammation‐induced fever depends on prostaglandin E2 production by brain endothelial cells and EP3 receptors in the median preoptic nucleus of the hypothalamus. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Blomqvist%2C+Anders%22">Blomqvist, Anders</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Acta+Physiologica%22">Acta Physiologica</searchLink>. Dec2024, Vol. 240 Issue 12, p1-3. 3p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22RNA+interference%22">RNA interference</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+receptors%22">Cell receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Small+interfering+RNA%22">Small interfering RNA</searchLink><br /><searchLink fieldCode="DE" term="%22Weight+loss%22">Weight loss</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+expression%22">Gene expression</searchLink><br /><searchLink fieldCode="DE" term="%22Prostaglandin+receptors%22">Prostaglandin receptors</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The article in Acta Physiologica discusses the critical role of prostaglandin E2 (PGE2) production in brain endothelial cells in generating fever, emphasizing its importance over other mechanisms. The study highlights that PGE2 synthesis and its binding to EP3 receptors in the median preoptic nucleus of the hypothalamus are essential for fever to occur. While the involvement of microglial cells in fever is debated, the evidence suggests that PGE2 synthesis by brain endothelial cells is a crucial step in the fever response. The findings caution against overinterpreting the role of microglia in fever and underscore the significance of PGE2 synthesis by brain endothelial cells in the process. [Extracted from the article] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=180775567 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1111/apha.14238 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 3 StartPage: 1 Subjects: – SubjectFull: RNA interference Type: general – SubjectFull: Cell receptors Type: general – SubjectFull: Small interfering RNA Type: general – SubjectFull: Weight loss Type: general – SubjectFull: Gene expression Type: general – SubjectFull: Prostaglandin receptors Type: general Titles: – TitleFull: Inflammation‐induced fever depends on prostaglandin E2 production by brain endothelial cells and EP3 receptors in the median preoptic nucleus of the hypothalamus. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Blomqvist, Anders IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2024 Type: published Y: 2024 Identifiers: – Type: issn-print Value: 17481708 Numbering: – Type: volume Value: 240 – Type: issue Value: 12 Titles: – TitleFull: Acta Physiologica Type: main |
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