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Predicting remission following CBT for childhood anxiety disorders: a machine learning approach.

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Title: Predicting remission following CBT for childhood anxiety disorders: a machine learning approach.
Authors: Bertie, Lizel-Antoinette, Quiroz, Juan C., Berkovsky, Shlomo, Arendt, Kristian, Bögels, Susan, Coleman, Jonathan R. I., Cooper, Peter, Creswell, Cathy, Eley, Thalia C., Hartman, Catharina, Fjermestadt, Krister, In-Albon, Tina, Lavallee, Kristen, Lester, Kathryn J., Lyneham, Heidi J., Marin, Carla E., McKinnon, Anna, McLellan, Lauren F., Meiser-Stedman, Richard, Nauta, Maaike
Source: Psychological Medicine. Dec2024, Vol. 54 Issue 16, p4612-4622. 11p.
Subjects: Anxiety disorders treatment, Risk assessment, Prediction models, Research funding, Disease remission, Descriptive statistics, Anxiety disorders, Cognitive therapy, Machine learning, Comorbidity, Mental depression, Children
Abstract: Background: The identification of predictors of treatment response is crucial for improving treatment outcome for children with anxiety disorders. Machine learning methods provide opportunities to identify combinations of factors that contribute to risk prediction models. Methods: A machine learning approach was applied to predict anxiety disorder remission in a large sample of 2114 anxious youth (5–18 years). Potential predictors included demographic, clinical, parental, and treatment variables with data obtained pre-treatment, post-treatment, and at least one follow-up. Results: All machine learning models performed similarly for remission outcomes, with AUC between 0.67 and 0.69. There was significant alignment between the factors that contributed to the models predicting two target outcomes: remission of all anxiety disorders and the primary anxiety disorder. Children who were older, had multiple anxiety disorders, comorbid depression, comorbid externalising disorders, received group treatment and therapy delivered by a more experienced therapist, and who had a parent with higher anxiety and depression symptoms, were more likely than other children to still meet criteria for anxiety disorders at the completion of therapy. In both models, the absence of a social anxiety disorder and being treated by a therapist with less experience contributed to the model predicting a higher likelihood of remission. Conclusions: These findings underscore the utility of prediction models that may indicate which children are more likely to remit or are more at risk of non-remission following CBT for childhood anxiety. [ABSTRACT FROM AUTHOR]
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Database: Psychology and Behavioral Sciences Collection
Description
Abstract:Background: The identification of predictors of treatment response is crucial for improving treatment outcome for children with anxiety disorders. Machine learning methods provide opportunities to identify combinations of factors that contribute to risk prediction models. Methods: A machine learning approach was applied to predict anxiety disorder remission in a large sample of 2114 anxious youth (5–18 years). Potential predictors included demographic, clinical, parental, and treatment variables with data obtained pre-treatment, post-treatment, and at least one follow-up. Results: All machine learning models performed similarly for remission outcomes, with AUC between 0.67 and 0.69. There was significant alignment between the factors that contributed to the models predicting two target outcomes: remission of all anxiety disorders and the primary anxiety disorder. Children who were older, had multiple anxiety disorders, comorbid depression, comorbid externalising disorders, received group treatment and therapy delivered by a more experienced therapist, and who had a parent with higher anxiety and depression symptoms, were more likely than other children to still meet criteria for anxiety disorders at the completion of therapy. In both models, the absence of a social anxiety disorder and being treated by a therapist with less experience contributed to the model predicting a higher likelihood of remission. Conclusions: These findings underscore the utility of prediction models that may indicate which children are more likely to remit or are more at risk of non-remission following CBT for childhood anxiety. [ABSTRACT FROM AUTHOR]
ISSN:00332917
DOI:10.1017/S0033291724002654