4D marmoset brain map reveals MRI and molecular signatures for onset of multiple sclerosis-like lesions.
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| Title: | 4D marmoset brain map reveals MRI and molecular signatures for onset of multiple sclerosis-like lesions. |
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| Authors: | Jing-Ping Lin, Brake, Alexis, Donadieu, Maxime, Lee, Amanda, Smith, Ginger, Hu, Kevin, Nair, Govind, Kawaguchi, Riki, Sati, Pascal, Geschwind, Daniel H., Jacobson, Steven, Schafer, Dorothy P., Reich, Daniel S. |
| Source: | Science (pre-March 2025). 2/28/2025, Vol. 387 Issue 6737, p945-945. 1p. 1 Color Photograph. |
| Subjects: | Marmosets, Brain mapping, Magnetic resonance imaging, Callithrix jacchus, Oligodendroglia |
| Abstract: | The article focuses on mapping multiple sclerosis (MS)-like lesion development in a marmoset model using magnetic resonance imaging (MRI), histopathology, and molecular profiling. Topics include early astrocytic signaling in perivascular and periventricular regions, an MRI biomarker for pre-demyelination hypercellularity, and the role of microglia, oligodendrocyte precursor cells (OPCs), and monocyte derivatives in lesion progression and repair. |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | The article focuses on mapping multiple sclerosis (MS)-like lesion development in a marmoset model using magnetic resonance imaging (MRI), histopathology, and molecular profiling. Topics include early astrocytic signaling in perivascular and periventricular regions, an MRI biomarker for pre-demyelination hypercellularity, and the role of microglia, oligodendrocyte precursor cells (OPCs), and monocyte derivatives in lesion progression and repair. |
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| ISSN: | 00368075 |
| DOI: | 10.1126/science.adp6325 |
