4D marmoset brain map reveals MRI and molecular signatures for onset of multiple sclerosis-like lesions.
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| Title: | 4D marmoset brain map reveals MRI and molecular signatures for onset of multiple sclerosis-like lesions. |
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| Authors: | Jing-Ping Lin, Brake, Alexis, Donadieu, Maxime, Lee, Amanda, Smith, Ginger, Hu, Kevin, Nair, Govind, Kawaguchi, Riki, Sati, Pascal, Geschwind, Daniel H., Jacobson, Steven, Schafer, Dorothy P., Reich, Daniel S. |
| Source: | Science (pre-March 2025). 2/28/2025, Vol. 387 Issue 6737, p945-945. 1p. 1 Color Photograph. |
| Subjects: | Marmosets, Brain mapping, Magnetic resonance imaging, Callithrix jacchus, Oligodendroglia |
| Abstract: | The article focuses on mapping multiple sclerosis (MS)-like lesion development in a marmoset model using magnetic resonance imaging (MRI), histopathology, and molecular profiling. Topics include early astrocytic signaling in perivascular and periventricular regions, an MRI biomarker for pre-demyelination hypercellularity, and the role of microglia, oligodendrocyte precursor cells (OPCs), and monocyte derivatives in lesion progression and repair. |
| Database: | Psychology and Behavioral Sciences Collection |
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| FullText | Links: – Type: pdflink Text: Availability: 1 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 183310476 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: 4D marmoset brain map reveals MRI and molecular signatures for onset of multiple sclerosis-like lesions. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Jing-Ping+Lin%22">Jing-Ping Lin</searchLink><br /><searchLink fieldCode="AR" term="%22Brake%2C+Alexis%22">Brake, Alexis</searchLink><br /><searchLink fieldCode="AR" term="%22Donadieu%2C+Maxime%22">Donadieu, Maxime</searchLink><br /><searchLink fieldCode="AR" term="%22Lee%2C+Amanda%22">Lee, Amanda</searchLink><br /><searchLink fieldCode="AR" term="%22Smith%2C+Ginger%22">Smith, Ginger</searchLink><br /><searchLink fieldCode="AR" term="%22Hu%2C+Kevin%22">Hu, Kevin</searchLink><br /><searchLink fieldCode="AR" term="%22Nair%2C+Govind%22">Nair, Govind</searchLink><br /><searchLink fieldCode="AR" term="%22Kawaguchi%2C+Riki%22">Kawaguchi, Riki</searchLink><br /><searchLink fieldCode="AR" term="%22Sati%2C+Pascal%22">Sati, Pascal</searchLink><br /><searchLink fieldCode="AR" term="%22Geschwind%2C+Daniel+H%2E%22">Geschwind, Daniel H.</searchLink><br /><searchLink fieldCode="AR" term="%22Jacobson%2C+Steven%22">Jacobson, Steven</searchLink><br /><searchLink fieldCode="AR" term="%22Schafer%2C+Dorothy+P%2E%22">Schafer, Dorothy P.</searchLink><br /><searchLink fieldCode="AR" term="%22Reich%2C+Daniel+S%2E%22">Reich, Daniel S.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Science+%28pre-March+2025%29%22">Science (pre-March 2025)</searchLink>. 2/28/2025, Vol. 387 Issue 6737, p945-945. 1p. 1 Color Photograph. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Marmosets%22">Marmosets</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+mapping%22">Brain mapping</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Callithrix+jacchus%22">Callithrix jacchus</searchLink><br /><searchLink fieldCode="DE" term="%22Oligodendroglia%22">Oligodendroglia</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The article focuses on mapping multiple sclerosis (MS)-like lesion development in a marmoset model using magnetic resonance imaging (MRI), histopathology, and molecular profiling. Topics include early astrocytic signaling in perivascular and periventricular regions, an MRI biomarker for pre-demyelination hypercellularity, and the role of microglia, oligodendrocyte precursor cells (OPCs), and monocyte derivatives in lesion progression and repair. |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=183310476 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1126/science.adp6325 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 1 StartPage: 945 Subjects: – SubjectFull: Marmosets Type: general – SubjectFull: Brain mapping Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Callithrix jacchus Type: general – SubjectFull: Oligodendroglia Type: general Titles: – TitleFull: 4D marmoset brain map reveals MRI and molecular signatures for onset of multiple sclerosis-like lesions. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Jing-Ping Lin – PersonEntity: Name: NameFull: Brake, Alexis – PersonEntity: Name: NameFull: Donadieu, Maxime – PersonEntity: Name: NameFull: Lee, Amanda – PersonEntity: Name: NameFull: Smith, Ginger – PersonEntity: Name: NameFull: Hu, Kevin – PersonEntity: Name: NameFull: Nair, Govind – PersonEntity: Name: NameFull: Kawaguchi, Riki – PersonEntity: Name: NameFull: Sati, Pascal – PersonEntity: Name: NameFull: Geschwind, Daniel H. – PersonEntity: Name: NameFull: Jacobson, Steven – PersonEntity: Name: NameFull: Schafer, Dorothy P. – PersonEntity: Name: NameFull: Reich, Daniel S. IsPartOfRelationships: – BibEntity: Dates: – D: 28 M: 02 Text: 2/28/2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 00368075 Numbering: – Type: volume Value: 387 – Type: issue Value: 6737 Titles: – TitleFull: Science (pre-March 2025) Type: main |
| ResultId | 1 |
