Early Alterations of Motor Learning and Corticostriatal Network Activity in a Huntington's Disease Mouse Model.
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| Title: | Early Alterations of Motor Learning and Corticostriatal Network Activity in a Huntington's Disease Mouse Model. |
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| Authors: | Badreddine, N. (AUTHOR), Appaix, F. (AUTHOR), Becq, G. (AUTHOR), Achard, S. (AUTHOR), Saudou, F. (AUTHOR), Fino, E. (AUTHOR) |
| Source: | European Journal of Neuroscience. Mar2025, Vol. 61 Issue 5, p1-14. 14p. |
| Subjects: | Huntington disease, Motor learning, Laboratory mice, Corpus striatum, Motor ability, Basal ganglia, Neurodegeneration |
| Abstract: | Huntington's disease (HD) is a neurodegenerative disorder that presents motor, cognitive, and psychiatric symptoms as it progresses. Prior to motor symptoms onset, alterations, and dysfunctions in the corticostriatal projections have been described along with cognitive deficits, but the sequence of early alterations of brain circuits is largely unknown. There is thus a crucial need to identify early alterations that precede symptoms and that could be used as potential early disease markers. Using an HD knock‐in mouse model (HdhCAG140/+) that recapitulates the human genetic alterations and that shows a late and progressive appearance of anatomical and behavioral deficits, we identified early alterations in the motor learning abilities of young mice, long before any motor coordination dysfunctions. In parallel, ex vivo two‐photon calcium recordings revealed that young HD mice have altered basal activity patterns in both the dorsomedial and dorsolateral parts of the striatum. In addition, although wild‐type mice display specific reorganization of the activity upon motor training, network alterations present in the basal state of non‐trained mice are not affected by motor training of HD mice. Our results thus identify early behavioral deficits and network alterations that could serve as early markers of the disease. [ABSTRACT FROM AUTHOR] |
| Copyright of European Journal of Neuroscience is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Huntington's disease (HD) is a neurodegenerative disorder that presents motor, cognitive, and psychiatric symptoms as it progresses. Prior to motor symptoms onset, alterations, and dysfunctions in the corticostriatal projections have been described along with cognitive deficits, but the sequence of early alterations of brain circuits is largely unknown. There is thus a crucial need to identify early alterations that precede symptoms and that could be used as potential early disease markers. Using an HD knock‐in mouse model (HdhCAG140/+) that recapitulates the human genetic alterations and that shows a late and progressive appearance of anatomical and behavioral deficits, we identified early alterations in the motor learning abilities of young mice, long before any motor coordination dysfunctions. In parallel, ex vivo two‐photon calcium recordings revealed that young HD mice have altered basal activity patterns in both the dorsomedial and dorsolateral parts of the striatum. In addition, although wild‐type mice display specific reorganization of the activity upon motor training, network alterations present in the basal state of non‐trained mice are not affected by motor training of HD mice. Our results thus identify early behavioral deficits and network alterations that could serve as early markers of the disease. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 0953816X |
| DOI: | 10.1111/ejn.70056 |
