Bibliographic Details
| Title: |
Brain Signatures of Very Early Cognitive Decline in Asymptomatic Middle‐Aged Offspring of People With Alzheimer's Disease. |
| Authors: |
Ramsingh, Nadia, Lin, Hung‐Mo, Ouyang, Yuxia, Ravona‐Springer, Ramit, Livny, Abigail, Soleimani, Laili, Bendlin, Barbara B., Matatov, Adar, Niv, Tal, Shamir, Tamar, Ganmore, Ithamar, Heymann, Anthony, Sano, Mary, Azuri, Joseph, Beeri, Michal Schnaider |
| Source: |
International Journal of Geriatric Psychiatry. Mar2025, Vol. 40 Issue 3, p1-10. 10p. |
| Subjects: |
Alzheimer's disease risk factors, Children of people with mental illness, Risk assessment, Research funding, Sex distribution, Questionnaires, Brain, Family history (Medicine), Age distribution, Descriptive statistics, Magnetic resonance imaging, Cerebral cortex, Age factors in disease, Longitudinal method, White matter (Nerve tissue), Cognition disorders, Educational attainment, Cognition, Middle age |
| Geographic Terms: |
Israel |
| Abstract: |
Objective: To assess the relationship of subtle preclinical cognitive changes with white matter microstructure and cortical volume in middle‐aged adults at high AD risk due to a parental history. Methods: Participants (n = 278) were AD patients' offspring from the Israel Registry for Alzheimer's Prevention study. Cognitively unimpaired‐decliners (CU‐D) were based on a linear regression model. In a subsample with MRI (n = 220), we examined relationships of CU‐D with white matter (WM) microstructure (fractional anisotropy [FA] and mean diffusivity [MD]) and cortical volume in brain regions commonly affected in AD. Results: CU‐D participants had lower FA in the superior longitudinal fasciculus (SLF) (p = < 0.001) and higher MD in the SLF (p = < 0.001), and cingulum adjacent to the corpus callosum (p = < 0.001) and genu (p = 0.006) compared to cognitively unimpaired‐stable (CU‐S) participants. The groups did not differ in cortical brain volumes. Conclusions: CU‐D participants had poorer WM microstructure in brain tracts affected early in AD. Early interventions can target individuals that fit the CU‐D criteria. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
