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Brain Signatures of Very Early Cognitive Decline in Asymptomatic Middle‐Aged Offspring of People With Alzheimer's Disease.

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Title: Brain Signatures of Very Early Cognitive Decline in Asymptomatic Middle‐Aged Offspring of People With Alzheimer's Disease.
Authors: Ramsingh, Nadia, Lin, Hung‐Mo, Ouyang, Yuxia, Ravona‐Springer, Ramit, Livny, Abigail, Soleimani, Laili, Bendlin, Barbara B., Matatov, Adar, Niv, Tal, Shamir, Tamar, Ganmore, Ithamar, Heymann, Anthony, Sano, Mary, Azuri, Joseph, Beeri, Michal Schnaider
Source: International Journal of Geriatric Psychiatry. Mar2025, Vol. 40 Issue 3, p1-10. 10p.
Subjects: Alzheimer's disease risk factors, Children of people with mental illness, Risk assessment, Research funding, Sex distribution, Questionnaires, Brain, Family history (Medicine), Age distribution, Descriptive statistics, Magnetic resonance imaging, Cerebral cortex, Age factors in disease, Longitudinal method, White matter (Nerve tissue), Cognition disorders, Educational attainment, Cognition, Middle age
Geographic Terms: Israel
Abstract: Objective: To assess the relationship of subtle preclinical cognitive changes with white matter microstructure and cortical volume in middle‐aged adults at high AD risk due to a parental history. Methods: Participants (n = 278) were AD patients' offspring from the Israel Registry for Alzheimer's Prevention study. Cognitively unimpaired‐decliners (CU‐D) were based on a linear regression model. In a subsample with MRI (n = 220), we examined relationships of CU‐D with white matter (WM) microstructure (fractional anisotropy [FA] and mean diffusivity [MD]) and cortical volume in brain regions commonly affected in AD. Results: CU‐D participants had lower FA in the superior longitudinal fasciculus (SLF) (p = < 0.001) and higher MD in the SLF (p = < 0.001), and cingulum adjacent to the corpus callosum (p = < 0.001) and genu (p = 0.006) compared to cognitively unimpaired‐stable (CU‐S) participants. The groups did not differ in cortical brain volumes. Conclusions: CU‐D participants had poorer WM microstructure in brain tracts affected early in AD. Early interventions can target individuals that fit the CU‐D criteria. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Geriatric Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Brain Signatures of Very Early Cognitive Decline in Asymptomatic Middle‐Aged Offspring of People With Alzheimer&#39;s Disease.
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  Data: Objective: To assess the relationship of subtle preclinical cognitive changes with white matter microstructure and cortical volume in middle‐aged adults at high AD risk due to a parental history. Methods: Participants (n = 278) were AD patients&#39; offspring from the Israel Registry for Alzheimer&#39;s Prevention study. Cognitively unimpaired‐decliners (CU‐D) were based on a linear regression model. In a subsample with MRI (n = 220), we examined relationships of CU‐D with white matter (WM) microstructure (fractional anisotropy [FA] and mean diffusivity [MD]) and cortical volume in brain regions commonly affected in AD. Results: CU‐D participants had lower FA in the superior longitudinal fasciculus (SLF) (p = &lt; 0.001) and higher MD in the SLF (p = &lt; 0.001), and cingulum adjacent to the corpus callosum (p = &lt; 0.001) and genu (p = 0.006) compared to cognitively unimpaired‐stable (CU‐S) participants. The groups did not differ in cortical brain volumes. Conclusions: CU‐D participants had poorer WM microstructure in brain tracts affected early in AD. Early interventions can target individuals that fit the CU‐D criteria. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of International Journal of Geriatric Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=184044996
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        Value: 10.1002/gps.70060
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        Text: English
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      – SubjectFull: Alzheimer's disease risk factors
        Type: general
      – SubjectFull: Children of people with mental illness
        Type: general
      – SubjectFull: Risk assessment
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      – SubjectFull: Research funding
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      – SubjectFull: Sex distribution
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      – SubjectFull: Descriptive statistics
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      – SubjectFull: Magnetic resonance imaging
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      – SubjectFull: Cerebral cortex
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      – SubjectFull: Age factors in disease
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      – SubjectFull: Cognition
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      – SubjectFull: Middle age
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      – SubjectFull: Israel
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      – TitleFull: Brain Signatures of Very Early Cognitive Decline in Asymptomatic Middle‐Aged Offspring of People With Alzheimer's Disease.
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              Text: Mar2025
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