Factors Distinguishing Nonsystemic Versus Systemic Vasculitic Peripheral Neuropathy: A Retrospective Cohort Study.
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| Title: | Factors Distinguishing Nonsystemic Versus Systemic Vasculitic Peripheral Neuropathy: A Retrospective Cohort Study. |
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| Authors: | Berling, Edouard (AUTHOR), Maisonobe, Thierry (AUTHOR), Morassi, Olivier (AUTHOR), Echaniz‐Laguna, Andoni (AUTHOR), Denier, Christian (AUTHOR), Le Guillou, Adrien (AUTHOR), Duschene, Mathilde (AUTHOR), Labeyrie, Céline (AUTHOR), Adam, Clovis (AUTHOR) |
| Source: | European Journal of Neurology. Apr2025, Vol. 32 Issue 4, p1-8. 8p. |
| Subjects: | Vasculitis, Peripheral neuropathy, Vascular diseases, Cohort analysis, Antinuclear factors, C-reactive protein, Diagnosis |
| Abstract: | Background: Prompt differentiation of nonsystemic vasculitic neuropathy (NSVN) from systemic vasculitic neuropathy (SVN) without antineutrophil cytoplasmic antibodies or organ involvement (SVN‐) is challenging but crucial given the differences in management. Our primary objective was to identify predictors of SVN‐ versus NSVN. Methods: We retrospectively identified patients seen at either of two centers for histologically definite or probable vasculitic neuropathy diagnosed as SVN‐ or NSVN. Clinical, electromyographic, laboratory, and histological data at diagnosis and last follow‐up were collected. Results: We included 98 patients, of whom 46 (47%) had NSVN and 52 (53%) SVN‐. Symptoms and neurophysiological findings did not significantly differ between the two groups. By univariate analysis, compared to the NSVN group, the SVN‐ group had more patients with C‐reactive protein ≥ 10 mg/L (44.2% vs. 17.4%, p < 0.01), antinuclear antibodies (42.3% vs. 21.7%, p = 0.04), and low C3 or C4 (23.1% vs. 4.3%, p = 0.02). All three associations were confirmed by multivariate analysis. By multivariate analysis adjusted for symptom duration, muscle vasculitis also was associated with SVN‐ (OR, 8.33; 95% CI, 2.63–25.00; p < 0.01). Conclusion: Simple, readily available laboratory and histological variables may help to rapidly distinguish SVN from NSVN. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Background: Prompt differentiation of nonsystemic vasculitic neuropathy (NSVN) from systemic vasculitic neuropathy (SVN) without antineutrophil cytoplasmic antibodies or organ involvement (SVN‐) is challenging but crucial given the differences in management. Our primary objective was to identify predictors of SVN‐ versus NSVN. Methods: We retrospectively identified patients seen at either of two centers for histologically definite or probable vasculitic neuropathy diagnosed as SVN‐ or NSVN. Clinical, electromyographic, laboratory, and histological data at diagnosis and last follow‐up were collected. Results: We included 98 patients, of whom 46 (47%) had NSVN and 52 (53%) SVN‐. Symptoms and neurophysiological findings did not significantly differ between the two groups. By univariate analysis, compared to the NSVN group, the SVN‐ group had more patients with C‐reactive protein ≥ 10 mg/L (44.2% vs. 17.4%, p < 0.01), antinuclear antibodies (42.3% vs. 21.7%, p = 0.04), and low C3 or C4 (23.1% vs. 4.3%, p = 0.02). All three associations were confirmed by multivariate analysis. By multivariate analysis adjusted for symptom duration, muscle vasculitis also was associated with SVN‐ (OR, 8.33; 95% CI, 2.63–25.00; p < 0.01). Conclusion: Simple, readily available laboratory and histological variables may help to rapidly distinguish SVN from NSVN. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 13515101 |
| DOI: | 10.1111/ene.70150 |
