View in EDS HTML Full Text PDF Full Text

Factors Distinguishing Nonsystemic Versus Systemic Vasculitic Peripheral Neuropathy: A Retrospective Cohort Study.

Saved in:
Bibliographic Details
Title: Factors Distinguishing Nonsystemic Versus Systemic Vasculitic Peripheral Neuropathy: A Retrospective Cohort Study.
Authors: Berling, Edouard (AUTHOR), Maisonobe, Thierry (AUTHOR), Morassi, Olivier (AUTHOR), Echaniz‐Laguna, Andoni (AUTHOR), Denier, Christian (AUTHOR), Le Guillou, Adrien (AUTHOR), Duschene, Mathilde (AUTHOR), Labeyrie, Céline (AUTHOR), Adam, Clovis (AUTHOR)
Source: European Journal of Neurology. Apr2025, Vol. 32 Issue 4, p1-8. 8p.
Subjects: Vasculitis, Peripheral neuropathy, Vascular diseases, Cohort analysis, Antinuclear factors, C-reactive protein, Diagnosis
Abstract: Background: Prompt differentiation of nonsystemic vasculitic neuropathy (NSVN) from systemic vasculitic neuropathy (SVN) without antineutrophil cytoplasmic antibodies or organ involvement (SVN‐) is challenging but crucial given the differences in management. Our primary objective was to identify predictors of SVN‐ versus NSVN. Methods: We retrospectively identified patients seen at either of two centers for histologically definite or probable vasculitic neuropathy diagnosed as SVN‐ or NSVN. Clinical, electromyographic, laboratory, and histological data at diagnosis and last follow‐up were collected. Results: We included 98 patients, of whom 46 (47%) had NSVN and 52 (53%) SVN‐. Symptoms and neurophysiological findings did not significantly differ between the two groups. By univariate analysis, compared to the NSVN group, the SVN‐ group had more patients with C‐reactive protein ≥ 10 mg/L (44.2% vs. 17.4%, p < 0.01), antinuclear antibodies (42.3% vs. 21.7%, p = 0.04), and low C3 or C4 (23.1% vs. 4.3%, p = 0.02). All three associations were confirmed by multivariate analysis. By multivariate analysis adjusted for symptom duration, muscle vasculitis also was associated with SVN‐ (OR, 8.33; 95% CI, 2.63–25.00; p < 0.01). Conclusion: Simple, readily available laboratory and histological variables may help to rapidly distinguish SVN from NSVN. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 184799784
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Factors Distinguishing Nonsystemic Versus Systemic Vasculitic Peripheral Neuropathy: A Retrospective Cohort Study.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Berling%2C+Edouard%22&quot;&gt;Berling, Edouard&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Maisonobe%2C+Thierry%22&quot;&gt;Maisonobe, Thierry&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Morassi%2C+Olivier%22&quot;&gt;Morassi, Olivier&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Echaniz‐Laguna%2C+Andoni%22&quot;&gt;Echaniz‐Laguna, Andoni&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Denier%2C+Christian%22&quot;&gt;Denier, Christian&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Le+Guillou%2C+Adrien%22&quot;&gt;Le Guillou, Adrien&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Duschene%2C+Mathilde%22&quot;&gt;Duschene, Mathilde&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Labeyrie%2C+C&#233;line%22&quot;&gt;Labeyrie, C&#233;line&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Adam%2C+Clovis%22&quot;&gt;Adam, Clovis&lt;/searchLink&gt; (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22European+Journal+of+Neurology%22&quot;&gt;European Journal of Neurology&lt;/searchLink&gt;. Apr2025, Vol. 32 Issue 4, p1-8. 8p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Vasculitis%22&quot;&gt;Vasculitis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Peripheral+neuropathy%22&quot;&gt;Peripheral neuropathy&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Vascular+diseases%22&quot;&gt;Vascular diseases&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cohort+analysis%22&quot;&gt;Cohort analysis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Antinuclear+factors%22&quot;&gt;Antinuclear factors&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22C-reactive+protein%22&quot;&gt;C-reactive protein&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Diagnosis%22&quot;&gt;Diagnosis&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Prompt differentiation of nonsystemic vasculitic neuropathy (NSVN) from systemic vasculitic neuropathy (SVN) without antineutrophil cytoplasmic antibodies or organ involvement (SVN‐) is challenging but crucial given the differences in management. Our primary objective was to identify predictors of SVN‐ versus NSVN. Methods: We retrospectively identified patients seen at either of two centers for histologically definite or probable vasculitic neuropathy diagnosed as SVN‐ or NSVN. Clinical, electromyographic, laboratory, and histological data at diagnosis and last follow‐up were collected. Results: We included 98 patients, of whom 46 (47%) had NSVN and 52 (53%) SVN‐. Symptoms and neurophysiological findings did not significantly differ between the two groups. By univariate analysis, compared to the NSVN group, the SVN‐ group had more patients with C‐reactive protein ≥ 10 mg/L (44.2% vs. 17.4%, p &lt; 0.01), antinuclear antibodies (42.3% vs. 21.7%, p = 0.04), and low C3 or C4 (23.1% vs. 4.3%, p = 0.02). All three associations were confirmed by multivariate analysis. By multivariate analysis adjusted for symptom duration, muscle vasculitis also was associated with SVN‐ (OR, 8.33; 95% CI, 2.63–25.00; p &lt; 0.01). Conclusion: Simple, readily available laboratory and histological variables may help to rapidly distinguish SVN from NSVN. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of European Journal of Neurology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=184799784
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1111/ene.70150
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 1
    Subjects:
      – SubjectFull: Vasculitis
        Type: general
      – SubjectFull: Peripheral neuropathy
        Type: general
      – SubjectFull: Vascular diseases
        Type: general
      – SubjectFull: Cohort analysis
        Type: general
      – SubjectFull: Antinuclear factors
        Type: general
      – SubjectFull: C-reactive protein
        Type: general
      – SubjectFull: Diagnosis
        Type: general
    Titles:
      – TitleFull: Factors Distinguishing Nonsystemic Versus Systemic Vasculitic Peripheral Neuropathy: A Retrospective Cohort Study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Berling, Edouard
      – PersonEntity:
          Name:
            NameFull: Maisonobe, Thierry
      – PersonEntity:
          Name:
            NameFull: Morassi, Olivier
      – PersonEntity:
          Name:
            NameFull: Echaniz‐Laguna, Andoni
      – PersonEntity:
          Name:
            NameFull: Denier, Christian
      – PersonEntity:
          Name:
            NameFull: Le Guillou, Adrien
      – PersonEntity:
          Name:
            NameFull: Duschene, Mathilde
      – PersonEntity:
          Name:
            NameFull: Labeyrie, Céline
      – PersonEntity:
          Name:
            NameFull: Adam, Clovis
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 04
              Text: Apr2025
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 13515101
          Numbering:
            – Type: volume
              Value: 32
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: European Journal of Neurology
              Type: main
ResultId 1