Decoding cholesteatoma radiological dimensions: unveiling the discrepancy between CT and MRI imaging and development of a predictive model based on CT and MRI volume comparison.
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| Title: | Decoding cholesteatoma radiological dimensions: unveiling the discrepancy between CT and MRI imaging and development of a predictive model based on CT and MRI volume comparison. |
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| Authors: | Covelli, Edoardo (AUTHOR), Bozzao, Alessandro (AUTHOR), Meliante, Piero Giuseppe (AUTHOR), Filippi, Chiara (AUTHOR), Pizzolante, Sofia (AUTHOR), Elfarargy, Haitham H. (AUTHOR), Romano, Andrea (AUTHOR), Barbara, Maurizio (AUTHOR) |
| Source: | Acta Oto-Laryngologica. Jun2025, Vol. 145 Issue 6, p469-475. 7p. |
| Subjects: | Statistical correlation, Prediction models, Academic medical centers, Temporal bone, Computed tomography, Clinical trials, Cholesteatoma, Magnetic resonance imaging, Descriptive statistics, Tertiary care, Longitudinal method, Experimental design, Research, Comparative studies, Data analysis software, Regression analysis, Ear surgery |
| Abstract (English): | Background: Cholesteatoma (CHO) presents a significant threat to middle ear integrity, potentially leading to severe complications. Radiological assessment is crucial for understanding CHO anatomy, with high-resolution CT scans commonly used despite limitations in sensitivity and size overestimation. Recent advancements in non-echo planar imaging (EPI) diffusion-weighted imaging (DWI) MRI offer improved sensitivity, but accessibility issues persist. Objectives: The objective of this study is to compare CHO volume, as measured by CT scans, and the gold standard non-EPI DWI MRI. Materials and methods: A prospective clinical trial involving 39 participants with middle-ear CHO compared CT and non-EPI DWI MRI volumes. Patients underwent both imaging modalities, and volumes were measured using a co-registration technique. Results: Median CHO volumes measured by MRI and CT showed a notable difference. The Bland–Altman plot indicated one outlier, removed for further analysis. Linear regression suggested a correlation, with CT volumes overestimating MRI volumes by a factor of four. Conclusions: Our study establishes a formula to estimate CHO size, highlighting the tendency of CT scans to overestimate volumes. While non-EPI DWI MRI remains the gold standard for accurate measurements, our findings emphasize the complementary roles of CT and MRI in CHO diagnosis and post-surgical follow-up through fusion techniques. [ABSTRACT FROM AUTHOR] |
| Abstract (Chinese): | 胆脂瘤 (CHO) 对中耳整体构成重大威胁, 可能导致严重并发症。放射学评估对于了解 CHO 解剖学至关重要, 尽管存在灵敏度和尺寸高估的局限性, 但高分辨率 CT 扫描仍被广泛使用。非回波平面成像 (EPI) 扩散加权成像 (DWI) MRI 的最新进展提供了更高的灵敏度, 但其可获得性问题顽固存在。 本研究的目的是比较 CT 扫描测量的 CHO 体积和黄金标准非 EPI DWI MRI。 一项涉及 39 名中耳 CHO 参与者的前瞻性临床试验比较了 CT体积 和非 EPI DWI MRI 体积。患者接受了两种成像方式, 并使用联合配准技术测量体积。 MRI 和 CT 测量的中位 CHO 体积显示出显著差异。 Bland–Altman图显示一个异常值, 已将其移除以进行进一步分析。线性回归分析表明存在着相关性, CT 体积比 MRI 体积高估了四倍。 我们的研究建立了一个估算 CHO 大小的公式, 强调了 CT扫描高估体积的趋势。虽然非 EPI DWI MRI 仍然是准确测量的黄金标准, 但我们的研究结果强调了 CT 和 MRI 在 CHO 诊断和通过融合技术进行术后随访中的互补作用。 [ABSTRACT FROM AUTHOR] |
| Copyright of Acta Oto-Laryngologica is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Background: Cholesteatoma (CHO) presents a significant threat to middle ear integrity, potentially leading to severe complications. Radiological assessment is crucial for understanding CHO anatomy, with high-resolution CT scans commonly used despite limitations in sensitivity and size overestimation. Recent advancements in non-echo planar imaging (EPI) diffusion-weighted imaging (DWI) MRI offer improved sensitivity, but accessibility issues persist. Objectives: The objective of this study is to compare CHO volume, as measured by CT scans, and the gold standard non-EPI DWI MRI. Materials and methods: A prospective clinical trial involving 39 participants with middle-ear CHO compared CT and non-EPI DWI MRI volumes. Patients underwent both imaging modalities, and volumes were measured using a co-registration technique. Results: Median CHO volumes measured by MRI and CT showed a notable difference. The Bland–Altman plot indicated one outlier, removed for further analysis. Linear regression suggested a correlation, with CT volumes overestimating MRI volumes by a factor of four. Conclusions: Our study establishes a formula to estimate CHO size, highlighting the tendency of CT scans to overestimate volumes. While non-EPI DWI MRI remains the gold standard for accurate measurements, our findings emphasize the complementary roles of CT and MRI in CHO diagnosis and post-surgical follow-up through fusion techniques. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 00016489 |
| DOI: | 10.1080/00016489.2025.2484560 |
