Lack of Synaptic Adhesion Proteins Makes Zebrafish More Anxious and Less Aggressive.
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| Title: | Lack of Synaptic Adhesion Proteins Makes Zebrafish More Anxious and Less Aggressive. |
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| Authors: | Adel, Maja R. (AUTHOR), Freudenberg, Florian (AUTHOR) |
| Source: | Acta Physiologica. Jul2025, Vol. 241 Issue 7, p1-3. 3p. |
| Subjects: | Anxiety, Animal aggression, Cell adhesion molecules, Mental illness, Neural development, Behavior genetics, Brachydanio, Gene expression |
| Abstract: | The article focuses on the investigation of the leucine‐rich repeat transmembrane protein 4 like 1 (lrrtm4l1) gene in zebrafish and its implications for behavioral, transcriptomic, and metabolomic changes related to neurodevelopmental and psychiatric disorders. The study identifies significant gene expression alterations in lrrtm4l1 knockout zebrafish, including upregulation of genes linked to cognition and downregulation of those associated with catecholamine synthesis. Behavioral tests indicate increased anxiety-like behavior and reduced aggression in lrrtm4l1−/− zebrafish, suggesting a role for this gene in psychiatric phenotypes. The findings highlight the potential of LRRTM4 as a target for neuropsychiatric interventions, particularly in conditions characterized by altered aggression and anxiety. [Extracted from the article] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | The article focuses on the investigation of the leucine‐rich repeat transmembrane protein 4 like 1 (lrrtm4l1) gene in zebrafish and its implications for behavioral, transcriptomic, and metabolomic changes related to neurodevelopmental and psychiatric disorders. The study identifies significant gene expression alterations in lrrtm4l1 knockout zebrafish, including upregulation of genes linked to cognition and downregulation of those associated with catecholamine synthesis. Behavioral tests indicate increased anxiety-like behavior and reduced aggression in lrrtm4l1−/− zebrafish, suggesting a role for this gene in psychiatric phenotypes. The findings highlight the potential of LRRTM4 as a target for neuropsychiatric interventions, particularly in conditions characterized by altered aggression and anxiety. [Extracted from the article] |
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| ISSN: | 17481708 |
| DOI: | 10.1111/apha.70065 |
