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Lack of Synaptic Adhesion Proteins Makes Zebrafish More Anxious and Less Aggressive.

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Title: Lack of Synaptic Adhesion Proteins Makes Zebrafish More Anxious and Less Aggressive.
Authors: Adel, Maja R. (AUTHOR), Freudenberg, Florian (AUTHOR)
Source: Acta Physiologica. Jul2025, Vol. 241 Issue 7, p1-3. 3p.
Subjects: Anxiety, Animal aggression, Cell adhesion molecules, Mental illness, Neural development, Behavior genetics, Brachydanio, Gene expression
Abstract: The article focuses on the investigation of the leucine‐rich repeat transmembrane protein 4 like 1 (lrrtm4l1) gene in zebrafish and its implications for behavioral, transcriptomic, and metabolomic changes related to neurodevelopmental and psychiatric disorders. The study identifies significant gene expression alterations in lrrtm4l1 knockout zebrafish, including upregulation of genes linked to cognition and downregulation of those associated with catecholamine synthesis. Behavioral tests indicate increased anxiety-like behavior and reduced aggression in lrrtm4l1−/− zebrafish, suggesting a role for this gene in psychiatric phenotypes. The findings highlight the potential of LRRTM4 as a target for neuropsychiatric interventions, particularly in conditions characterized by altered aggression and anxiety. [Extracted from the article]
Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Lack of Synaptic Adhesion Proteins Makes Zebrafish More Anxious and Less Aggressive.
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  Data: <searchLink fieldCode="AR" term="%22Adel%2C+Maja+R%2E%22">Adel, Maja R.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Freudenberg%2C+Florian%22">Freudenberg, Florian</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Physiologica%22">Acta Physiologica</searchLink>. Jul2025, Vol. 241 Issue 7, p1-3. 3p.
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  Data: <searchLink fieldCode="DE" term="%22Anxiety%22">Anxiety</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+aggression%22">Animal aggression</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+adhesion+molecules%22">Cell adhesion molecules</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+illness%22">Mental illness</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+development%22">Neural development</searchLink><br /><searchLink fieldCode="DE" term="%22Behavior+genetics%22">Behavior genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Brachydanio%22">Brachydanio</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+expression%22">Gene expression</searchLink>
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  Label: Abstract
  Group: Ab
  Data: The article focuses on the investigation of the leucine‐rich repeat transmembrane protein 4 like 1 (lrrtm4l1) gene in zebrafish and its implications for behavioral, transcriptomic, and metabolomic changes related to neurodevelopmental and psychiatric disorders. The study identifies significant gene expression alterations in lrrtm4l1 knockout zebrafish, including upregulation of genes linked to cognition and downregulation of those associated with catecholamine synthesis. Behavioral tests indicate increased anxiety-like behavior and reduced aggression in lrrtm4l1−/− zebrafish, suggesting a role for this gene in psychiatric phenotypes. The findings highlight the potential of LRRTM4 as a target for neuropsychiatric interventions, particularly in conditions characterized by altered aggression and anxiety. [Extracted from the article]
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  Group: Ab
  Data: <i>Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=186162278
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    Identifiers:
      – Type: doi
        Value: 10.1111/apha.70065
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      – Code: eng
        Text: English
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        PageCount: 3
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    Subjects:
      – SubjectFull: Anxiety
        Type: general
      – SubjectFull: Animal aggression
        Type: general
      – SubjectFull: Cell adhesion molecules
        Type: general
      – SubjectFull: Mental illness
        Type: general
      – SubjectFull: Neural development
        Type: general
      – SubjectFull: Behavior genetics
        Type: general
      – SubjectFull: Brachydanio
        Type: general
      – SubjectFull: Gene expression
        Type: general
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      – TitleFull: Lack of Synaptic Adhesion Proteins Makes Zebrafish More Anxious and Less Aggressive.
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            – D: 01
              M: 07
              Text: Jul2025
              Type: published
              Y: 2025
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