Bibliographic Details
| Title: |
Estrogen Control of Social Behaviors. |
| Authors: |
Lawal, Oluwadamilola O. (AUTHOR), Lin, Dayu (AUTHOR), Lischinsky, Julieta E. (AUTHOR) |
| Source: |
Annual Review of Neuroscience. Jul2025, Vol. 48 Issue 1, p125-147. 24p. |
| Subjects: |
Model organisms, Hormone receptors, Estrogen receptors, Social networks, Transgenic organisms |
| Abstract: |
Social behaviors, including parental care, mating, and fighting, all depend on the hormonal milieu of an organism. Decades of work highlighted estrogen as a key hormonal controller of social behaviors, exerting its influence primarily through binding to estrogen receptor alpha (ERα). Recent technological advances in chemogenetics, optogenetics, gene editing, and transgenic model organisms have allowed for a detailed understanding of the neuronal subpopulations and circuits for estrogen action across Esr1-expressing interconnected brain regions. Focusing on rodent studies, in this review we examine classical and contemporary research demonstrating the multifaceted role of estrogen and ERα in regulating social behaviors in a sex-specific and context-dependent manner. We highlight gaps in knowledge, particularly a missing link in the molecular cascade that allows estrogen to exert such a diverse behavioral repertoire through the coordination of gene expression changes. Understanding the molecular and cellular basis of ERα's action in social behaviors provides insights into the broader mechanisms of hormone-driven behavior modulation across the lifespan. [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
