Estrogen Control of Social Behaviors.
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| Title: | Estrogen Control of Social Behaviors. |
|---|---|
| Authors: | Lawal, Oluwadamilola O. (AUTHOR), Lin, Dayu (AUTHOR), Lischinsky, Julieta E. (AUTHOR) |
| Source: | Annual Review of Neuroscience. Jul2025, Vol. 48 Issue 1, p125-147. 24p. |
| Subjects: | Model organisms, Hormone receptors, Estrogen receptors, Social networks, Transgenic organisms |
| Abstract: | Social behaviors, including parental care, mating, and fighting, all depend on the hormonal milieu of an organism. Decades of work highlighted estrogen as a key hormonal controller of social behaviors, exerting its influence primarily through binding to estrogen receptor alpha (ERα). Recent technological advances in chemogenetics, optogenetics, gene editing, and transgenic model organisms have allowed for a detailed understanding of the neuronal subpopulations and circuits for estrogen action across Esr1-expressing interconnected brain regions. Focusing on rodent studies, in this review we examine classical and contemporary research demonstrating the multifaceted role of estrogen and ERα in regulating social behaviors in a sex-specific and context-dependent manner. We highlight gaps in knowledge, particularly a missing link in the molecular cascade that allows estrogen to exert such a diverse behavioral repertoire through the coordination of gene expression changes. Understanding the molecular and cellular basis of ERα's action in social behaviors provides insights into the broader mechanisms of hormone-driven behavior modulation across the lifespan. [ABSTRACT FROM AUTHOR] |
| Copyright of Annual Review of Neuroscience is the property of Annual Reviews Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
| FullText | Text: Availability: 0 |
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| Header | DbId: pbh DbLabel: Psychology and Behavioral Sciences Collection An: 186725419 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Estrogen Control of Social Behaviors. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Lawal%2C+Oluwadamilola+O%2E%22">Lawal, Oluwadamilola O.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lin%2C+Dayu%22">Lin, Dayu</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lischinsky%2C+Julieta+E%2E%22">Lischinsky, Julieta E.</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Annual+Review+of+Neuroscience%22">Annual Review of Neuroscience</searchLink>. Jul2025, Vol. 48 Issue 1, p125-147. 24p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Model+organisms%22">Model organisms</searchLink><br /><searchLink fieldCode="DE" term="%22Hormone+receptors%22">Hormone receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Estrogen+receptors%22">Estrogen receptors</searchLink><br /><searchLink fieldCode="DE" term="%22Social+networks%22">Social networks</searchLink><br /><searchLink fieldCode="DE" term="%22Transgenic+organisms%22">Transgenic organisms</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Social behaviors, including parental care, mating, and fighting, all depend on the hormonal milieu of an organism. Decades of work highlighted estrogen as a key hormonal controller of social behaviors, exerting its influence primarily through binding to estrogen receptor alpha (ERα). Recent technological advances in chemogenetics, optogenetics, gene editing, and transgenic model organisms have allowed for a detailed understanding of the neuronal subpopulations and circuits for estrogen action across Esr1-expressing interconnected brain regions. Focusing on rodent studies, in this review we examine classical and contemporary research demonstrating the multifaceted role of estrogen and ERα in regulating social behaviors in a sex-specific and context-dependent manner. We highlight gaps in knowledge, particularly a missing link in the molecular cascade that allows estrogen to exert such a diverse behavioral repertoire through the coordination of gene expression changes. Understanding the molecular and cellular basis of ERα's action in social behaviors provides insights into the broader mechanisms of hormone-driven behavior modulation across the lifespan. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Annual Review of Neuroscience is the property of Annual Reviews Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=186725419 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1146/annurev-neuro-112723-041639 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 24 StartPage: 125 Subjects: – SubjectFull: Model organisms Type: general – SubjectFull: Hormone receptors Type: general – SubjectFull: Estrogen receptors Type: general – SubjectFull: Social networks Type: general – SubjectFull: Transgenic organisms Type: general Titles: – TitleFull: Estrogen Control of Social Behaviors. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lawal, Oluwadamilola O. – PersonEntity: Name: NameFull: Lin, Dayu – PersonEntity: Name: NameFull: Lischinsky, Julieta E. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 0147006X Numbering: – Type: volume Value: 48 – Type: issue Value: 1 Titles: – TitleFull: Annual Review of Neuroscience Type: main |
| ResultId | 1 |
