Oppositional Defiant Disorder in Autism and ADHD.

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Title: Oppositional Defiant Disorder in Autism and ADHD.
Authors: Mayes, Susan D. (AUTHOR), Pardej, Sara K. (AUTHOR), Waschbusch, Daniel A. (AUTHOR)
Source: Journal of Autism & Developmental Disorders. Nov2025, Vol. 55 Issue 11, p4092-4105. 14p.
Subjects: Attention-deficit hyperactivity disorder, T-test (Statistics), Autism, Retrospective studies, Classification of mental disorders, Descriptive statistics, Analysis of covariance, Chi-squared test, Asperger's syndrome, Comparative studies, Factor analysis, Oppositional defiant disorder in children, Comorbidity, Regression analysis, Disease complications, Children
Abstract: Our study compared oppositional defiant disorder (ODD) in children with autism to ADHD-Combined presentation and ADHD-Inattentive presentation. Mothers of 2,400 children 3–17 years old with autism and/or ADHD completed the Pediatric Behavior Scale. ADHD-Combined was most strongly associated with ODD, with an ODD prevalence of 53% in children with ADHD-Combined only. When autism was added to ADHD-Combined, prevalence increased to 62% and the ODD score increased significantly. Autism+ADHD-Inattentive, Autism Only, and ADHD-Inattentive Only had ODD prevalences of 28%, 24% and 14%. In each diagnostic group, ODD had the same two factors (irritable/angry and oppositional/defiant); demographic differences between children with and without ODD were few; and correlations between ODD and conduct problems were large, correlations with depression were medium, and correlations with anxiety were small. However, ODD scores differed significantly between groups (Autism+ADHD-Combined > ADHD-Combined Only > Autism+ADHD-Inattentive and Autism Only > ADHD-Inattentive Only). The irritable/angry ODD component was greater in Autism+ADHD-Combined than in ADHD-Combined Only, whereas the oppositional/defiant component did not differ between the two groups. Autism was a significant independent risk factor for ODD, particularly the irritable/angry ODD component, but ADHD-Combined was the strongest risk factor. Therefore, the high co-occurrence of ADHD-Combined in autism (80% in our study) largely explains the high prevalence of ODD in autism. ADHD-Combined, autism, and ODD are highly comorbid (55–90%). Clinicians should assess all three disorders in referred children and provide evidence-based interventions to improve current functioning and outcomes for children with these disorders and reduce family and caretaker stress. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Oppositional Defiant Disorder in Autism and ADHD.
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  Data: <searchLink fieldCode="AR" term="%22Mayes%2C+Susan+D%2E%22">Mayes, Susan D.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pardej%2C+Sara+K%2E%22">Pardej, Sara K.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Waschbusch%2C+Daniel+A%2E%22">Waschbusch, Daniel A.</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Autism+%26+Developmental+Disorders%22">Journal of Autism & Developmental Disorders</searchLink>. Nov2025, Vol. 55 Issue 11, p4092-4105. 14p.
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– Name: Abstract
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  Data: Our study compared oppositional defiant disorder (ODD) in children with autism to ADHD-Combined presentation and ADHD-Inattentive presentation. Mothers of 2,400 children 3–17 years old with autism and/or ADHD completed the Pediatric Behavior Scale. ADHD-Combined was most strongly associated with ODD, with an ODD prevalence of 53% in children with ADHD-Combined only. When autism was added to ADHD-Combined, prevalence increased to 62% and the ODD score increased significantly. Autism+ADHD-Inattentive, Autism Only, and ADHD-Inattentive Only had ODD prevalences of 28%, 24% and 14%. In each diagnostic group, ODD had the same two factors (irritable/angry and oppositional/defiant); demographic differences between children with and without ODD were few; and correlations between ODD and conduct problems were large, correlations with depression were medium, and correlations with anxiety were small. However, ODD scores differed significantly between groups (Autism+ADHD-Combined > ADHD-Combined Only > Autism+ADHD-Inattentive and Autism Only > ADHD-Inattentive Only). The irritable/angry ODD component was greater in Autism+ADHD-Combined than in ADHD-Combined Only, whereas the oppositional/defiant component did not differ between the two groups. Autism was a significant independent risk factor for ODD, particularly the irritable/angry ODD component, but ADHD-Combined was the strongest risk factor. Therefore, the high co-occurrence of ADHD-Combined in autism (80% in our study) largely explains the high prevalence of ODD in autism. ADHD-Combined, autism, and ODD are highly comorbid (55–90%). Clinicians should assess all three disorders in referred children and provide evidence-based interventions to improve current functioning and outcomes for children with these disorders and reduce family and caretaker stress. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Autism & Developmental Disorders is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1007/s10803-024-06437-9
    Languages:
      – Code: eng
        Text: English
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      Pagination:
        PageCount: 14
        StartPage: 4092
    Subjects:
      – SubjectFull: Attention-deficit hyperactivity disorder
        Type: general
      – SubjectFull: T-test (Statistics)
        Type: general
      – SubjectFull: Autism
        Type: general
      – SubjectFull: Retrospective studies
        Type: general
      – SubjectFull: Classification of mental disorders
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Analysis of covariance
        Type: general
      – SubjectFull: Chi-squared test
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      – SubjectFull: Asperger's syndrome
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      – SubjectFull: Comparative studies
        Type: general
      – SubjectFull: Factor analysis
        Type: general
      – SubjectFull: Oppositional defiant disorder in children
        Type: general
      – SubjectFull: Comorbidity
        Type: general
      – SubjectFull: Regression analysis
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      – SubjectFull: Disease complications
        Type: general
      – SubjectFull: Children
        Type: general
    Titles:
      – TitleFull: Oppositional Defiant Disorder in Autism and ADHD.
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            NameFull: Mayes, Susan D.
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              M: 11
              Text: Nov2025
              Type: published
              Y: 2025
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