View in EDS

Estrogen modulates reward prediction errors and reinforcement learning.

Saved in:
Bibliographic Details
Title: Estrogen modulates reward prediction errors and reinforcement learning.
Authors: Golden, Carla E. M. (AUTHOR), Martin, Audrey C. (AUTHOR), Kaur, Daljit (AUTHOR), Mah, Andrew (AUTHOR), Levy, Diana H. (AUTHOR), Yamaguchi, Takashi (AUTHOR), Lasek, Amy W. (AUTHOR), Lin, Dayu (AUTHOR), Aoki, Chiye (AUTHOR), Constantinople, Christine M. (AUTHOR)
Source: Nature Neuroscience. Dec2025, Vol. 28 Issue 12, p2502-2514. 13p.
Abstract: Gonadal hormones act throughout the brain and modulate psychiatric symptoms. Yet how hormones influence cognitive processes is unclear. Exogenous 17β-estradiol, the most potent estrogen, modulates dopamine in the nucleus accumbens core, which instantiates reward prediction errors (RPEs), the difference between received and expected reward. Here we show that following endogenous increases in 17β-estradiol, dopamine RPEs and behavioral sensitivity to previous rewards are enhanced, and nucleus accumbens core dopamine reuptake proteins are reduced. Rats adjusted how quickly they initiated trials in a task with varying reward states, balancing effort against expected rewards. Nucleus accumbens core dopamine reflected RPEs that influenced rats' initiation times. Higher 17β-estradiol predicted greater sensitivity to reward states and larger RPEs. Proteomics revealed reduced dopamine transporter expression following 17β-estradiol increases. Finally, knockdown of midbrain estrogen receptors suppressed sensitivity to reward states. Therefore, endogenous 17β-estradiol predicts dopamine reuptake and RPE signaling, and causally dictates the impact of previous rewards on behavior. Dopamine encoding of reward prediction errors naturally fluctuates over females' reproductive cycles with estrogenic signaling due to reduced expression of dopamine reuptake proteins. [ABSTRACT FROM AUTHOR]
Copyright of Nature Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Description
Abstract:Gonadal hormones act throughout the brain and modulate psychiatric symptoms. Yet how hormones influence cognitive processes is unclear. Exogenous 17β-estradiol, the most potent estrogen, modulates dopamine in the nucleus accumbens core, which instantiates reward prediction errors (RPEs), the difference between received and expected reward. Here we show that following endogenous increases in 17β-estradiol, dopamine RPEs and behavioral sensitivity to previous rewards are enhanced, and nucleus accumbens core dopamine reuptake proteins are reduced. Rats adjusted how quickly they initiated trials in a task with varying reward states, balancing effort against expected rewards. Nucleus accumbens core dopamine reflected RPEs that influenced rats' initiation times. Higher 17β-estradiol predicted greater sensitivity to reward states and larger RPEs. Proteomics revealed reduced dopamine transporter expression following 17β-estradiol increases. Finally, knockdown of midbrain estrogen receptors suppressed sensitivity to reward states. Therefore, endogenous 17β-estradiol predicts dopamine reuptake and RPE signaling, and causally dictates the impact of previous rewards on behavior. Dopamine encoding of reward prediction errors naturally fluctuates over females' reproductive cycles with estrogenic signaling due to reduced expression of dopamine reuptake proteins. [ABSTRACT FROM AUTHOR]
ISSN:10976256
DOI:10.1038/s41593-025-02104-z