Exploration of the Value of Optical Coherence Tomography (OCT) and OCT Angiography in Differentiating Between Major Depressive Disorder and Borderline Personality Disorder.
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| Title: | Exploration of the Value of Optical Coherence Tomography (OCT) and OCT Angiography in Differentiating Between Major Depressive Disorder and Borderline Personality Disorder. |
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| Authors: | Xiao, Qian (AUTHOR), Shen, Liying (AUTHOR), Li, Fangling (AUTHOR), Jiang, Furong (AUTHOR), Xu, Bei (AUTHOR) |
| Source: | International Journal of Methods in Psychiatric Research. Dec2025, Vol. 34 Issue 4, p1-12. 12p. |
| Subjects: | Optical coherence tomography, Borderline personality disorder, Mental depression, Retinal blood vessels, Microcirculation disorders, Biomarkers, Neurophysiology |
| Abstract: | Background: Major depressive disorder (MDD) and borderline personality disorder (BPD) are psychiatric conditions with overlapping clinical features but distinct pathologies. This study aims to explore the microvascular changes in superficial retinal capillary plexus (SRCP) in patients between MDD and BPD using Optical Coherence Tomography (OCT) and Optical coherence tomography angiography (OCTA), as well as determine their clinical diagnostic value. Methods: The study involved 35 MDD patients, 36 BPD patients, and 36 healthy controls (HCs). OCTA and OCT were used to assess macular vessel density (MVD) and peripapillary vessel density (PVD), retinal nerve fiber layer (RNFL), and central retinal thickness (CRT). The study also evaluated the correlation of these ocular parameters with clinical symptoms. Results: Both MDD and BPD patients showed significant reductions in MVD, RNFL and CRT compared to HCs (all p < 0.05). BPD patients exhibited more pronounced decreases in the foveal area, RNFL and CRT than MDD patients (all p < 0.05). These ocular changes were associated with BPD symptom severity (all p < 0.05). The RNFL and CRT demonstrated potential as diagnostic markers for BPD (AUROCs of 0.625 and 0.695, p < 0.05). Conclusions: OCT and OCTA might differentiate between MDD and BPD by identifying specific ocular changes, suggesting distinct neurobiological mechanisms for each disorder. These technologies hold promise for improving diagnostic accuracy. [ABSTRACT FROM AUTHOR] |
| Copyright of International Journal of Methods in Psychiatric Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Background: Major depressive disorder (MDD) and borderline personality disorder (BPD) are psychiatric conditions with overlapping clinical features but distinct pathologies. This study aims to explore the microvascular changes in superficial retinal capillary plexus (SRCP) in patients between MDD and BPD using Optical Coherence Tomography (OCT) and Optical coherence tomography angiography (OCTA), as well as determine their clinical diagnostic value. Methods: The study involved 35 MDD patients, 36 BPD patients, and 36 healthy controls (HCs). OCTA and OCT were used to assess macular vessel density (MVD) and peripapillary vessel density (PVD), retinal nerve fiber layer (RNFL), and central retinal thickness (CRT). The study also evaluated the correlation of these ocular parameters with clinical symptoms. Results: Both MDD and BPD patients showed significant reductions in MVD, RNFL and CRT compared to HCs (all p < 0.05). BPD patients exhibited more pronounced decreases in the foveal area, RNFL and CRT than MDD patients (all p < 0.05). These ocular changes were associated with BPD symptom severity (all p < 0.05). The RNFL and CRT demonstrated potential as diagnostic markers for BPD (AUROCs of 0.625 and 0.695, p < 0.05). Conclusions: OCT and OCTA might differentiate between MDD and BPD by identifying specific ocular changes, suggesting distinct neurobiological mechanisms for each disorder. These technologies hold promise for improving diagnostic accuracy. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 10498931 |
| DOI: | 10.1002/mpr.70043 |
