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Exploration of the Value of Optical Coherence Tomography (OCT) and OCT Angiography in Differentiating Between Major Depressive Disorder and Borderline Personality Disorder.

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Title: Exploration of the Value of Optical Coherence Tomography (OCT) and OCT Angiography in Differentiating Between Major Depressive Disorder and Borderline Personality Disorder.
Authors: Xiao, Qian (AUTHOR), Shen, Liying (AUTHOR), Li, Fangling (AUTHOR), Jiang, Furong (AUTHOR), Xu, Bei (AUTHOR)
Source: International Journal of Methods in Psychiatric Research. Dec2025, Vol. 34 Issue 4, p1-12. 12p.
Subjects: Optical coherence tomography, Borderline personality disorder, Mental depression, Retinal blood vessels, Microcirculation disorders, Biomarkers, Neurophysiology
Abstract: Background: Major depressive disorder (MDD) and borderline personality disorder (BPD) are psychiatric conditions with overlapping clinical features but distinct pathologies. This study aims to explore the microvascular changes in superficial retinal capillary plexus (SRCP) in patients between MDD and BPD using Optical Coherence Tomography (OCT) and Optical coherence tomography angiography (OCTA), as well as determine their clinical diagnostic value. Methods: The study involved 35 MDD patients, 36 BPD patients, and 36 healthy controls (HCs). OCTA and OCT were used to assess macular vessel density (MVD) and peripapillary vessel density (PVD), retinal nerve fiber layer (RNFL), and central retinal thickness (CRT). The study also evaluated the correlation of these ocular parameters with clinical symptoms. Results: Both MDD and BPD patients showed significant reductions in MVD, RNFL and CRT compared to HCs (all p < 0.05). BPD patients exhibited more pronounced decreases in the foveal area, RNFL and CRT than MDD patients (all p < 0.05). These ocular changes were associated with BPD symptom severity (all p < 0.05). The RNFL and CRT demonstrated potential as diagnostic markers for BPD (AUROCs of 0.625 and 0.695, p < 0.05). Conclusions: OCT and OCTA might differentiate between MDD and BPD by identifying specific ocular changes, suggesting distinct neurobiological mechanisms for each disorder. These technologies hold promise for improving diagnostic accuracy. [ABSTRACT FROM AUTHOR]
Copyright of International Journal of Methods in Psychiatric Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Label: Title
  Group: Ti
  Data: Exploration of the Value of Optical Coherence Tomography (OCT) and OCT Angiography in Differentiating Between Major Depressive Disorder and Borderline Personality Disorder.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Xiao%2C+Qian%22&quot;&gt;Xiao, Qian&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Shen%2C+Liying%22&quot;&gt;Shen, Liying&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Li%2C+Fangling%22&quot;&gt;Li, Fangling&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Jiang%2C+Furong%22&quot;&gt;Jiang, Furong&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Xu%2C+Bei%22&quot;&gt;Xu, Bei&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22International+Journal+of+Methods+in+Psychiatric+Research%22&quot;&gt;International Journal of Methods in Psychiatric Research&lt;/searchLink&gt;. Dec2025, Vol. 34 Issue 4, p1-12. 12p.
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  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Optical+coherence+tomography%22&quot;&gt;Optical coherence tomography&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Borderline+personality+disorder%22&quot;&gt;Borderline personality disorder&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Mental+depression%22&quot;&gt;Mental depression&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Retinal+blood+vessels%22&quot;&gt;Retinal blood vessels&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Microcirculation+disorders%22&quot;&gt;Microcirculation disorders&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Biomarkers%22&quot;&gt;Biomarkers&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Neurophysiology%22&quot;&gt;Neurophysiology&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Major depressive disorder (MDD) and borderline personality disorder (BPD) are psychiatric conditions with overlapping clinical features but distinct pathologies. This study aims to explore the microvascular changes in superficial retinal capillary plexus (SRCP) in patients between MDD and BPD using Optical Coherence Tomography (OCT) and Optical coherence tomography angiography (OCTA), as well as determine their clinical diagnostic value. Methods: The study involved 35 MDD patients, 36 BPD patients, and 36 healthy controls (HCs). OCTA and OCT were used to assess macular vessel density (MVD) and peripapillary vessel density (PVD), retinal nerve fiber layer (RNFL), and central retinal thickness (CRT). The study also evaluated the correlation of these ocular parameters with clinical symptoms. Results: Both MDD and BPD patients showed significant reductions in MVD, RNFL and CRT compared to HCs (all p &lt; 0.05). BPD patients exhibited more pronounced decreases in the foveal area, RNFL and CRT than MDD patients (all p &lt; 0.05). These ocular changes were associated with BPD symptom severity (all p &lt; 0.05). The RNFL and CRT demonstrated potential as diagnostic markers for BPD (AUROCs of 0.625 and 0.695, p &lt; 0.05). Conclusions: OCT and OCTA might differentiate between MDD and BPD by identifying specific ocular changes, suggesting distinct neurobiological mechanisms for each disorder. These technologies hold promise for improving diagnostic accuracy. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of International Journal of Methods in Psychiatric Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1002/mpr.70043
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      – Code: eng
        Text: English
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        PageCount: 12
        StartPage: 1
    Subjects:
      – SubjectFull: Optical coherence tomography
        Type: general
      – SubjectFull: Borderline personality disorder
        Type: general
      – SubjectFull: Mental depression
        Type: general
      – SubjectFull: Retinal blood vessels
        Type: general
      – SubjectFull: Microcirculation disorders
        Type: general
      – SubjectFull: Biomarkers
        Type: general
      – SubjectFull: Neurophysiology
        Type: general
    Titles:
      – TitleFull: Exploration of the Value of Optical Coherence Tomography (OCT) and OCT Angiography in Differentiating Between Major Depressive Disorder and Borderline Personality Disorder.
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            NameFull: Xiao, Qian
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            NameFull: Shen, Liying
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            NameFull: Li, Fangling
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            NameFull: Jiang, Furong
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            – D: 01
              M: 12
              Text: Dec2025
              Type: published
              Y: 2025
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            – TitleFull: International Journal of Methods in Psychiatric Research
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