Bibliographic Details
| Title: |
Do Andean Aymara High‐Altitude–Enriched Genetic Variants Protect Europeans Against Acute Mountain Sickness? |
| Authors: |
Prchal, Josef T. (AUTHOR), Burtscher, Martin (AUTHOR), Kim, Soo Jin (AUTHOR), Wille, Maria (AUTHOR), Amaru, Ricardo (AUTHOR), Song, Jihyun (AUTHOR) |
| Source: |
Acta Physiologica. Feb2026, Vol. 242 Issue 2, p1-4. 4p. |
| Subjects: |
Mountain sickness, Genetic variation, Inflammation, Physiological adaptation, NF-kappa B, Biomarkers, Altitudes, Ethnic groups |
| Abstract: |
The article focuses on the genetic factors influencing acute mountain sickness (AMS) susceptibility in relation to high-altitude populations, particularly the Aymara and Tibetan groups. It highlights that while certain genetic variants are associated with AMS, they do not fully predict susceptibility, indicating the involvement of additional genetic determinants. The study identifies specific Aymara-enriched haplotypes, particularly in the NFKB1 gene, that may confer protective effects against AMS by modulating inflammatory responses and oxygenation during acute hypoxia. The findings suggest that these genetic adaptations could be relevant for understanding hypoxia tolerance in non-Andean populations and may serve as biomarkers for identifying individuals at risk for AMS. [Extracted from the article] |
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| Database: |
Psychology and Behavioral Sciences Collection |
