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Do Andean Aymara High‐Altitude–Enriched Genetic Variants Protect Europeans Against Acute Mountain Sickness?

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Title: Do Andean Aymara High‐Altitude–Enriched Genetic Variants Protect Europeans Against Acute Mountain Sickness?
Authors: Prchal, Josef T. (AUTHOR), Burtscher, Martin (AUTHOR), Kim, Soo Jin (AUTHOR), Wille, Maria (AUTHOR), Amaru, Ricardo (AUTHOR), Song, Jihyun (AUTHOR)
Source: Acta Physiologica. Feb2026, Vol. 242 Issue 2, p1-4. 4p.
Subjects: Mountain sickness, Genetic variation, Inflammation, Physiological adaptation, NF-kappa B, Biomarkers, Altitudes, Ethnic groups
Abstract: The article focuses on the genetic factors influencing acute mountain sickness (AMS) susceptibility in relation to high-altitude populations, particularly the Aymara and Tibetan groups. It highlights that while certain genetic variants are associated with AMS, they do not fully predict susceptibility, indicating the involvement of additional genetic determinants. The study identifies specific Aymara-enriched haplotypes, particularly in the NFKB1 gene, that may confer protective effects against AMS by modulating inflammatory responses and oxygenation during acute hypoxia. The findings suggest that these genetic adaptations could be relevant for understanding hypoxia tolerance in non-Andean populations and may serve as biomarkers for identifying individuals at risk for AMS. [Extracted from the article]
Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
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AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Do Andean Aymara High‐Altitude–Enriched Genetic Variants Protect Europeans Against Acute Mountain Sickness?
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  Data: <searchLink fieldCode="AR" term="%22Prchal%2C+Josef+T%2E%22">Prchal, Josef T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Burtscher%2C+Martin%22">Burtscher, Martin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kim%2C+Soo+Jin%22">Kim, Soo Jin</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wille%2C+Maria%22">Wille, Maria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Amaru%2C+Ricardo%22">Amaru, Ricardo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Song%2C+Jihyun%22">Song, Jihyun</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Acta+Physiologica%22">Acta Physiologica</searchLink>. Feb2026, Vol. 242 Issue 2, p1-4. 4p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Mountain+sickness%22">Mountain sickness</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+variation%22">Genetic variation</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammation%22">Inflammation</searchLink><br /><searchLink fieldCode="DE" term="%22Physiological+adaptation%22">Physiological adaptation</searchLink><br /><searchLink fieldCode="DE" term="%22NF-kappa+B%22">NF-kappa B</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Altitudes%22">Altitudes</searchLink><br /><searchLink fieldCode="DE" term="%22Ethnic+groups%22">Ethnic groups</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The article focuses on the genetic factors influencing acute mountain sickness (AMS) susceptibility in relation to high-altitude populations, particularly the Aymara and Tibetan groups. It highlights that while certain genetic variants are associated with AMS, they do not fully predict susceptibility, indicating the involvement of additional genetic determinants. The study identifies specific Aymara-enriched haplotypes, particularly in the NFKB1 gene, that may confer protective effects against AMS by modulating inflammatory responses and oxygenation during acute hypoxia. The findings suggest that these genetic adaptations could be relevant for understanding hypoxia tolerance in non-Andean populations and may serve as biomarkers for identifying individuals at risk for AMS. [Extracted from the article]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Physiologica is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=191106244
RecordInfo BibRecord:
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    Identifiers:
      – Type: doi
        Value: 10.1111/apha.70154
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 4
        StartPage: 1
    Subjects:
      – SubjectFull: Mountain sickness
        Type: general
      – SubjectFull: Genetic variation
        Type: general
      – SubjectFull: Inflammation
        Type: general
      – SubjectFull: Physiological adaptation
        Type: general
      – SubjectFull: NF-kappa B
        Type: general
      – SubjectFull: Biomarkers
        Type: general
      – SubjectFull: Altitudes
        Type: general
      – SubjectFull: Ethnic groups
        Type: general
    Titles:
      – TitleFull: Do Andean Aymara High‐Altitude–Enriched Genetic Variants Protect Europeans Against Acute Mountain Sickness?
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            NameFull: Prchal, Josef T.
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            NameFull: Burtscher, Martin
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            NameFull: Kim, Soo Jin
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            NameFull: Wille, Maria
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            NameFull: Amaru, Ricardo
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            NameFull: Song, Jihyun
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              M: 02
              Text: Feb2026
              Type: published
              Y: 2026
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              Value: 242
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