Mild motor signs and depression: more than just medication side effects?
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| Title: | Mild motor signs and depression: more than just medication side effects? |
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| Authors: | Luca, Antonina (AUTHOR), Luca, Maria (AUTHOR), Kasper, Siegfried (AUTHOR), Zohar, Joseph (AUTHOR), Souery, Daniel (AUTHOR), Montgomery, Stuart (AUTHOR), Ferentinos, Panagiotis (AUTHOR), Rujescu, Dan (AUTHOR), Mendlewicz, Julien (AUTHOR), Zanardi, Raffaele (AUTHOR), Ferri, Raffaella (AUTHOR), Lanuzza, Bartolo (AUTHOR), Pecorino, Basilio (AUTHOR), Baune, Bernhard T. (AUTHOR), Fanelli, Giuseppe (AUTHOR), Fabbri, Chiara (AUTHOR), Serretti, Alessandro (AUTHOR) |
| Source: | European Archives of Psychiatry & Clinical Neuroscience. Mar2026, Vol. 276 Issue 2, p451-457. 7p. |
| Subjects: | Mental depression, Treatment effectiveness, Neurologic manifestations of general diseases, Dystonia, Muscle rigidity, Drugs, Hypokinesia |
| Abstract: | The relationship between major depressive disorder (MDD) and mild motor signs (MMS) remains to be elucidated. The present study aims to assess the association between neurological symptoms and medications and treatment response. Neurological signs in 790 patients with MDD were correlated with treatment outcome. Three hundred ten (39.2%) were responders and 480 (60.8%) were non-responders. 342 (43.3%) presented neurological signs. In the whole sample negative associations between dystonia and rigidity and various medications was observed. Non-response was associated with dystonia, rigidity, and hypokinesia independent from age and medications. This study highlighted an association between MMS and specific medications. Moreover, MMS were associated with non-response to treatment, regardless of medication use. This may suggest that a subgroup of patients with MDD may respond less to therapy because of an underlying still undetected neurological disorder. [ABSTRACT FROM AUTHOR] |
| Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | The relationship between major depressive disorder (MDD) and mild motor signs (MMS) remains to be elucidated. The present study aims to assess the association between neurological symptoms and medications and treatment response. Neurological signs in 790 patients with MDD were correlated with treatment outcome. Three hundred ten (39.2%) were responders and 480 (60.8%) were non-responders. 342 (43.3%) presented neurological signs. In the whole sample negative associations between dystonia and rigidity and various medications was observed. Non-response was associated with dystonia, rigidity, and hypokinesia independent from age and medications. This study highlighted an association between MMS and specific medications. Moreover, MMS were associated with non-response to treatment, regardless of medication use. This may suggest that a subgroup of patients with MDD may respond less to therapy because of an underlying still undetected neurological disorder. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 09401334 |
| DOI: | 10.1007/s00406-025-02015-x |
