View in EDS HTML Full Text PDF Full Text

Mild motor signs and depression: more than just medication side effects?

Saved in:
Bibliographic Details
Title: Mild motor signs and depression: more than just medication side effects?
Authors: Luca, Antonina (AUTHOR), Luca, Maria (AUTHOR), Kasper, Siegfried (AUTHOR), Zohar, Joseph (AUTHOR), Souery, Daniel (AUTHOR), Montgomery, Stuart (AUTHOR), Ferentinos, Panagiotis (AUTHOR), Rujescu, Dan (AUTHOR), Mendlewicz, Julien (AUTHOR), Zanardi, Raffaele (AUTHOR), Ferri, Raffaella (AUTHOR), Lanuzza, Bartolo (AUTHOR), Pecorino, Basilio (AUTHOR), Baune, Bernhard T. (AUTHOR), Fanelli, Giuseppe (AUTHOR), Fabbri, Chiara (AUTHOR), Serretti, Alessandro (AUTHOR)
Source: European Archives of Psychiatry & Clinical Neuroscience. Mar2026, Vol. 276 Issue 2, p451-457. 7p.
Subjects: Mental depression, Treatment effectiveness, Neurologic manifestations of general diseases, Dystonia, Muscle rigidity, Drugs, Hypokinesia
Abstract: The relationship between major depressive disorder (MDD) and mild motor signs (MMS) remains to be elucidated. The present study aims to assess the association between neurological symptoms and medications and treatment response. Neurological signs in 790 patients with MDD were correlated with treatment outcome. Three hundred ten (39.2%) were responders and 480 (60.8%) were non-responders. 342 (43.3%) presented neurological signs. In the whole sample negative associations between dystonia and rigidity and various medications was observed. Non-response was associated with dystonia, rigidity, and hypokinesia independent from age and medications. This study highlighted an association between MMS and specific medications. Moreover, MMS were associated with non-response to treatment, regardless of medication use. This may suggest that a subgroup of patients with MDD may respond less to therapy because of an underlying still undetected neurological disorder. [ABSTRACT FROM AUTHOR]
Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 192008786
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Mild motor signs and depression: more than just medication side effects?
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Luca%2C+Antonina%22">Luca, Antonina</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Luca%2C+Maria%22">Luca, Maria</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kasper%2C+Siegfried%22">Kasper, Siegfried</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zohar%2C+Joseph%22">Zohar, Joseph</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Souery%2C+Daniel%22">Souery, Daniel</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Montgomery%2C+Stuart%22">Montgomery, Stuart</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ferentinos%2C+Panagiotis%22">Ferentinos, Panagiotis</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rujescu%2C+Dan%22">Rujescu, Dan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mendlewicz%2C+Julien%22">Mendlewicz, Julien</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zanardi%2C+Raffaele%22">Zanardi, Raffaele</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ferri%2C+Raffaella%22">Ferri, Raffaella</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lanuzza%2C+Bartolo%22">Lanuzza, Bartolo</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pecorino%2C+Basilio%22">Pecorino, Basilio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Baune%2C+Bernhard+T%2E%22">Baune, Bernhard T.</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fanelli%2C+Giuseppe%22">Fanelli, Giuseppe</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fabbri%2C+Chiara%22">Fabbri, Chiara</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Serretti%2C+Alessandro%22">Serretti, Alessandro</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22European+Archives+of+Psychiatry+%26+Clinical+Neuroscience%22">European Archives of Psychiatry & Clinical Neuroscience</searchLink>. Mar2026, Vol. 276 Issue 2, p451-457. 7p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Neurologic+manifestations+of+general+diseases%22">Neurologic manifestations of general diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Dystonia%22">Dystonia</searchLink><br /><searchLink fieldCode="DE" term="%22Muscle+rigidity%22">Muscle rigidity</searchLink><br /><searchLink fieldCode="DE" term="%22Drugs%22">Drugs</searchLink><br /><searchLink fieldCode="DE" term="%22Hypokinesia%22">Hypokinesia</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The relationship between major depressive disorder (MDD) and mild motor signs (MMS) remains to be elucidated. The present study aims to assess the association between neurological symptoms and medications and treatment response. Neurological signs in 790 patients with MDD were correlated with treatment outcome. Three hundred ten (39.2%) were responders and 480 (60.8%) were non-responders. 342 (43.3%) presented neurological signs. In the whole sample negative associations between dystonia and rigidity and various medications was observed. Non-response was associated with dystonia, rigidity, and hypokinesia independent from age and medications. This study highlighted an association between MMS and specific medications. Moreover, MMS were associated with non-response to treatment, regardless of medication use. This may suggest that a subgroup of patients with MDD may respond less to therapy because of an underlying still undetected neurological disorder. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of European Archives of Psychiatry & Clinical Neuroscience is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=192008786
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00406-025-02015-x
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 7
        StartPage: 451
    Subjects:
      – SubjectFull: Mental depression
        Type: general
      – SubjectFull: Treatment effectiveness
        Type: general
      – SubjectFull: Neurologic manifestations of general diseases
        Type: general
      – SubjectFull: Dystonia
        Type: general
      – SubjectFull: Muscle rigidity
        Type: general
      – SubjectFull: Drugs
        Type: general
      – SubjectFull: Hypokinesia
        Type: general
    Titles:
      – TitleFull: Mild motor signs and depression: more than just medication side effects?
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Luca, Antonina
      – PersonEntity:
          Name:
            NameFull: Luca, Maria
      – PersonEntity:
          Name:
            NameFull: Kasper, Siegfried
      – PersonEntity:
          Name:
            NameFull: Zohar, Joseph
      – PersonEntity:
          Name:
            NameFull: Souery, Daniel
      – PersonEntity:
          Name:
            NameFull: Montgomery, Stuart
      – PersonEntity:
          Name:
            NameFull: Ferentinos, Panagiotis
      – PersonEntity:
          Name:
            NameFull: Rujescu, Dan
      – PersonEntity:
          Name:
            NameFull: Mendlewicz, Julien
      – PersonEntity:
          Name:
            NameFull: Zanardi, Raffaele
      – PersonEntity:
          Name:
            NameFull: Ferri, Raffaella
      – PersonEntity:
          Name:
            NameFull: Lanuzza, Bartolo
      – PersonEntity:
          Name:
            NameFull: Pecorino, Basilio
      – PersonEntity:
          Name:
            NameFull: Baune, Bernhard T.
      – PersonEntity:
          Name:
            NameFull: Fanelli, Giuseppe
      – PersonEntity:
          Name:
            NameFull: Fabbri, Chiara
      – PersonEntity:
          Name:
            NameFull: Serretti, Alessandro
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 03
              Text: Mar2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 09401334
          Numbering:
            – Type: volume
              Value: 276
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: European Archives of Psychiatry & Clinical Neuroscience
              Type: main
ResultId 1