Association Between Sleep Quality and Clinical-Cognitive Parameters in Multiple Sclerosis: A Multidisciplinary Cross-Sectional Study.
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| Title: | Association Between Sleep Quality and Clinical-Cognitive Parameters in Multiple Sclerosis: A Multidisciplinary Cross-Sectional Study. |
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| Alternate Title: | Multipl Sklerozda Uyku Kalitesi ile Klinik-Bilişsel Parametreler Arasındaki İlişki: Multidiscipliner Kesitsel Bir Çalışma. |
| Authors: | Sarıdaş, Furkan (AUTHOR), Hojjati, Farid (AUTHOR), Özpar, Rıfat (AUTHOR), Dinç, Yasemin (AUTHOR), Akarsu, Emel Oğuz (AUTHOR), Minaz, Sema Nur (AUTHOR), Demiralay, Ahmet (AUTHOR), Koç, Emine Rabia (AUTHOR), Hakyemez, Bahattin (AUTHOR), Demir, Aylin Bican (AUTHOR) |
| Source: | Journal of Turkish Sleep Medicine. Mar2026, Vol. 13 Issue 1, p32-41. 10p. |
| Subjects: | Brain stem anatomy, Spinal cord diseases, Pearson correlation (Statistics), Statistical correlation, Cross-sectional method, Multiple sclerosis, Cognitive testing, Health status indicators, Sleep latency, Data analysis, Body mass index, Disease duration, Brain, Kruskal-Wallis Test, Fisher exact test, Sex distribution, Retrospective studies, Magnetic resonance imaging, Functional status, Mann Whitney U Test, Age distribution, Chi-squared test, Descriptive statistics, Medical records, Acquisition of data, One-way analysis of variance, Statistics, Quality of life, Geriatric Depression Scale, Sleep quality, Sociodemographic factors, Neuroradiology, Walking speed, Body movement, Psychological tests, Disease relapse, Data analysis software, Sleep hygiene, Physical mobility, Mental depression, Disease complications, Psychosocial factors |
| Abstract (English): | Objective: Sleep disturbances are a common symptom among patients with multiple sclerosis (MS). The Pittsburgh Sleep Quality Index (PSQI) is a reliable and practical tool for assessing sleep quality. The present study examined the association between sleep quality and clinical and radiologic characteristics in individuals with MS. Materials and Methods: In this retrospective study, 137 patients with MS (PwMS) were included following stringent clinical, radiologic, and psychiatric exclusion criteria. Demographic, clinical, cognitive, and neuroimaging data were extracted from medical records. Sleep quality was assessed using the PSQI, with a global score ≥5 indicating poor sleep quality. Results: Among the 137 PwMS, no significant differences were observed in demographic, clinical, cognitive, or radiologic parameters between those with good and poor sleep quality. However, walking speed was significantly slower in poor sleepers (p = 0.005). Sleep onset latency and subjective sleep quality were strongly correlated with overall PSQI scores. In contrast, lesion location, corpus callosum index, and measures of brainstem or spinal cord atrophy showed no association with sleep quality. Conclusion: Sleep quality is adversely affected in PwMS and correlates with lower-limb physical performance. Patients' self-assessments of sleep quality appear consistent. Prolonged sleep onset latency is an important factor, while the effects of sleep duration and disturbance are less significant. [ABSTRACT FROM AUTHOR] |
| Abstract (Turkish): | Amaç: Uyku bozuklukları, multipl skleroz (MS) hastalarında sık görülen bir semptomdur. Pittsburgh Uyku Kalitesi Endeksi (PSQI), uyku kalitesini değerlendirmek için güvenilir ve pratik bir araçtır. Bu çalışma, MS hastalarında uyku kalitesi ile klinik ve radyolojik özellikler arasındaki ilişkileri incelemiştir. Gereç ve Yöntem: Bu retrospektif çalışmada, sıkı klinik, radyolojik ve psikiyatrik dışlama kriterleri doğrultusunda 137 MS hastası (PwMS) dahil edildi. Demografik, klinik, bilişsel ve nörogörüntüleme verileri tıbbi kayıtlardan çıkarıldı. Uyku kalitesi PSQI kullanılarak değerlendirildi ve genel puan ≥5 olanlar kötü uyku kalitesine sahip olarak kabul edildi. Bulgular: Yüz otuz yedi MS hastası arasında, iyi ve kötü uyku kalitesine sahip olanlar arasında demografik, klinik, bilişsel veya radyolojik parametrelerde anlamlı bir fark gözlenmedi. Ancak, kötü uyuyanlarda yürüme hızı anlamlı olarak daha yavaştı (p = 0,005). Uykuya dalma süresi ve öznel uyku kalitesi, genel PSQI puanları ile güçlü bir korelasyon gösterdi. Buna karşın, lezyonun yeri, korpus kallosum indeksi ve beyin sapı veya omurilik atrofisi ölçümleri uyku kalitesi ile herhangi bir ilişki göstermedi. Sonuç: MS hastalarında uyku kalitesi olumsuz etkilenir ve alt ekstremite fiziksel performansı ile ilişkilidir. Hastaların uyku kalitesine ilişkin öz değerlendirmeleri tutarlı görünmektedir. Uykuya dalma süresinin uzaması önemli bir faktördür, ancak uyku süresi ve uyku bozukluğunun etkileri daha az önemlidir. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Turkish Sleep Medicine is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Objective: Sleep disturbances are a common symptom among patients with multiple sclerosis (MS). The Pittsburgh Sleep Quality Index (PSQI) is a reliable and practical tool for assessing sleep quality. The present study examined the association between sleep quality and clinical and radiologic characteristics in individuals with MS. Materials and Methods: In this retrospective study, 137 patients with MS (PwMS) were included following stringent clinical, radiologic, and psychiatric exclusion criteria. Demographic, clinical, cognitive, and neuroimaging data were extracted from medical records. Sleep quality was assessed using the PSQI, with a global score ≥5 indicating poor sleep quality. Results: Among the 137 PwMS, no significant differences were observed in demographic, clinical, cognitive, or radiologic parameters between those with good and poor sleep quality. However, walking speed was significantly slower in poor sleepers (p = 0.005). Sleep onset latency and subjective sleep quality were strongly correlated with overall PSQI scores. In contrast, lesion location, corpus callosum index, and measures of brainstem or spinal cord atrophy showed no association with sleep quality. Conclusion: Sleep quality is adversely affected in PwMS and correlates with lower-limb physical performance. Patients' self-assessments of sleep quality appear consistent. Prolonged sleep onset latency is an important factor, while the effects of sleep duration and disturbance are less significant. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 21481504 |
| DOI: | 10.4274/jtsm.galenos.2025.43265 |
