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Risk of major psychiatric disorder after adolescent pregnancy: A nationwide cohort study of 149,870 girls.

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Title: Risk of major psychiatric disorder after adolescent pregnancy: A nationwide cohort study of 149,870 girls.
Authors: Hsu, Tien‐Wei (AUTHOR), Li, Jia‐Ru (AUTHOR), Tsai, Shih‐Jen (AUTHOR), Bai, Ya‐Mei (AUTHOR), Su, Tung‐Ping (AUTHOR), Chen, Tzeng‐Ji (AUTHOR), Hsu, Ju‐Wei (AUTHOR), Chen, Mu‐Hong (AUTHOR), Liang, Chih‐Sung (AUTHOR)
Source: Psychiatry & Clinical Neurosciences. Jun2026, Vol. 80 Issue 6, p519-526. 8p.
Subjects: Teenage pregnancy, Bipolar disorder, Mental depression, Schizophrenia, Mental health screening, Cohort analysis, Disease risk factors, Psychiatric diagnosis
Abstract: Aim: Adolescent pregnancy is a global public health concern associated with increased risks of physical health, mental well‐being, and social functioning; however, its potential to increase the long‐term risk of major psychiatric disorder (MPD) remains underexplored. Methods: Between 1996 and 2013, a cohort of 29,974 girls with adolescent pregnancy without MPD before and 1:4 matched controls based on age, family income, residence location, and individual psychiatric comorbidity were enrolled. A Cox regression model was used, adjusted for potential confounders, to estimate the risk of schizophrenia, bipolar disorder, and major depressive disorder (MDD). Results: After adjusting for confounding factors, adolescent pregnancy was associated with significantly increased risks of bipolar disorder (hazard ratio 1.44; 95% confidence interval 1.20–1.72) and MDD (1.88; 1.76–2.00), but not schizophrenia (0.94; 0.73–1.21), compared to the control group. These associations persisted after excluding the first 3 years of follow‐up, with elevated risks of bipolar disorder (1.27; 1.05–1.54) and MDD (1.61; 1.50–1.72) among adolescents with pregnancy compared to controls. Conclusions: These results underscore the importance of implementing long‐term mental health surveillance strategies for young mothers who experience adolescent pregnancy. [ABSTRACT FROM AUTHOR]
Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
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  Data: Risk of major psychiatric disorder after adolescent pregnancy: A nationwide cohort study of 149,870 girls.
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  Data: <searchLink fieldCode="AR" term="%22Hsu%2C+Tien‐Wei%22">Hsu, Tien‐Wei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Jia‐Ru%22">Li, Jia‐Ru</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tsai%2C+Shih‐Jen%22">Tsai, Shih‐Jen</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Bai%2C+Ya‐Mei%22">Bai, Ya‐Mei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Su%2C+Tung‐Ping%22">Su, Tung‐Ping</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Tzeng‐Ji%22">Chen, Tzeng‐Ji</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hsu%2C+Ju‐Wei%22">Hsu, Ju‐Wei</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chen%2C+Mu‐Hong%22">Chen, Mu‐Hong</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Liang%2C+Chih‐Sung%22">Liang, Chih‐Sung</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Psychiatry+%26+Clinical+Neurosciences%22">Psychiatry & Clinical Neurosciences</searchLink>. Jun2026, Vol. 80 Issue 6, p519-526. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Teenage+pregnancy%22">Teenage pregnancy</searchLink><br /><searchLink fieldCode="DE" term="%22Bipolar+disorder%22">Bipolar disorder</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+depression%22">Mental depression</searchLink><br /><searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Mental+health+screening%22">Mental health screening</searchLink><br /><searchLink fieldCode="DE" term="%22Cohort+analysis%22">Cohort analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+risk+factors%22">Disease risk factors</searchLink><br /><searchLink fieldCode="DE" term="%22Psychiatric+diagnosis%22">Psychiatric diagnosis</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Aim: Adolescent pregnancy is a global public health concern associated with increased risks of physical health, mental well‐being, and social functioning; however, its potential to increase the long‐term risk of major psychiatric disorder (MPD) remains underexplored. Methods: Between 1996 and 2013, a cohort of 29,974 girls with adolescent pregnancy without MPD before and 1:4 matched controls based on age, family income, residence location, and individual psychiatric comorbidity were enrolled. A Cox regression model was used, adjusted for potential confounders, to estimate the risk of schizophrenia, bipolar disorder, and major depressive disorder (MDD). Results: After adjusting for confounding factors, adolescent pregnancy was associated with significantly increased risks of bipolar disorder (hazard ratio 1.44; 95% confidence interval 1.20–1.72) and MDD (1.88; 1.76–2.00), but not schizophrenia (0.94; 0.73–1.21), compared to the control group. These associations persisted after excluding the first 3 years of follow‐up, with elevated risks of bipolar disorder (1.27; 1.05–1.54) and MDD (1.61; 1.50–1.72) among adolescents with pregnancy compared to controls. Conclusions: These results underscore the importance of implementing long‐term mental health surveillance strategies for young mothers who experience adolescent pregnancy. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Psychiatry & Clinical Neurosciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1111/pcn.70054
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        Text: English
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      – SubjectFull: Bipolar disorder
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      – SubjectFull: Mental depression
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      – SubjectFull: Schizophrenia
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      – SubjectFull: Disease risk factors
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              Text: Jun2026
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              Y: 2026
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