Investigation of the Relationship Between Restless Legs Syndrome and Sleep Quality in Multiple Sclerosis Patients.
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| Title: | Investigation of the Relationship Between Restless Legs Syndrome and Sleep Quality in Multiple Sclerosis Patients. |
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| Authors: | Arıkan, Fatma Akkoyun (AUTHOR), Akdağ, Gönül (AUTHOR), Çetiner, Mustafa (AUTHOR), Kabay, Sibel Canbaz (AUTHOR) |
| Source: | Journal of Turkish Sleep Medicine / Türk Uyku Tıbbı Dergisi. Jun2026, Vol. 13 Issue 2, p1-6. 6p. |
| Subjects: | Cross-sectional method, Disabilities, Pearson correlation (Statistics), Multiple sclerosis, Disease duration, Ferritin, T-test (Statistics), Fatigue (Physiology), Questionnaires, Immunotherapy, Unemployment, Fisher exact test, Logistic regression analysis, Severity of illness index, Magnetic resonance imaging, Disease prevalence, Multivariate analysis, Mann Whitney U Test, Chi-squared test, Descriptive statistics, Odds ratio, Restless legs syndrome, Sleep quality, Data analysis software, Disease complications |
| Geographic Terms: | Türkiye |
| Abstract: | Objective This study aimed to determine the prevalence of restless legs syndrome (RLS) in patients with multiple sclerosis (MS) and to evaluate its effect on sleep quality. Materials and Methods This cross–sectional study was approved by the Ethics Committee of Kütahya Health Sciences University. A total of 151 patients with a confirmed diagnosis of MS were included. The Cambridge–Hopkins RLS Questionnaire, RLS Severity Scale, and Pittsburgh Sleep Quality Index (PSQI) were administered. Demographic, clinical, and radiological data were recorded. Patients were divided into two groups according to the presence of RLS, and appropriate parametric and non–parametric statistical tests were used for comparisons. Results The mean age of the participants was 40.6 ± 8.6 years, and 68.9% were female. The prevalence of RLS was 37.7%. Patients with RLS were older and had higher Expanded Disability Status Scale scores, a greater proportion of secondary progressive MS and primary progressive MS subtypes, and more frequent spinal lesions (p < 0.05). Poor sleep quality was observed in 63.2% of patients with RLS (p = 0.01). Logistic regression analysis showed that the presence of RLS increased the risk of PSQI by 3.37–fold (p = 0.006), and a family history of RLS was also an independent risk factor (p = 0.01). Conclusion RLS is common among MS patients and is associated with PSQI. The presence of RLS, spinal lesions, higher disability levels, and older age negatively affect sleep quality. Early recognition and management of RLS in MS patients may improve sleep quality and overall quality of life. [ABSTRACT FROM AUTHOR] |
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| Database: | Psychology and Behavioral Sciences Collection |
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| Abstract: | Objective This study aimed to determine the prevalence of restless legs syndrome (RLS) in patients with multiple sclerosis (MS) and to evaluate its effect on sleep quality. Materials and Methods This cross–sectional study was approved by the Ethics Committee of Kütahya Health Sciences University. A total of 151 patients with a confirmed diagnosis of MS were included. The Cambridge–Hopkins RLS Questionnaire, RLS Severity Scale, and Pittsburgh Sleep Quality Index (PSQI) were administered. Demographic, clinical, and radiological data were recorded. Patients were divided into two groups according to the presence of RLS, and appropriate parametric and non–parametric statistical tests were used for comparisons. Results The mean age of the participants was 40.6 ± 8.6 years, and 68.9% were female. The prevalence of RLS was 37.7%. Patients with RLS were older and had higher Expanded Disability Status Scale scores, a greater proportion of secondary progressive MS and primary progressive MS subtypes, and more frequent spinal lesions (p < 0.05). Poor sleep quality was observed in 63.2% of patients with RLS (p = 0.01). Logistic regression analysis showed that the presence of RLS increased the risk of PSQI by 3.37–fold (p = 0.006), and a family history of RLS was also an independent risk factor (p = 0.01). Conclusion RLS is common among MS patients and is associated with PSQI. The presence of RLS, spinal lesions, higher disability levels, and older age negatively affect sleep quality. Early recognition and management of RLS in MS patients may improve sleep quality and overall quality of life. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 21481504 |
| DOI: | 10.4274/jtsm.galenos.2025.49389 |
