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Comorbid Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder in a Patient with 6q25.1–Q25.3 Microdeletion: A Case Report.

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Title: Comorbid Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder in a Patient with 6q25.1–Q25.3 Microdeletion: A Case Report.
Authors: Sezgin, Mehmet (AUTHOR), Koyuncu, Oğuzhan (AUTHOR), Güneş, Mustafa (AUTHOR), Yıldırım Budak, Burcu (AUTHOR)
Source: Developmental Neuropsychology. 2026, Vol. 51 Issue 3/4, p207-214. 8p.
Subjects: Autism spectrum disorders, Attention-deficit hyperactivity disorder, DNA copy number variations, Behavior genetics, Emotional stability, Comorbidity, Olanzapine
Abstract: 6q25 microdeletion is a rare syndrome associated with intellectual disability and dysmorphism. However, comorbid Autism Spectrum Disorder (ASD) and Attention Deficit and Hyperactivity Disorder (ADHD) are poorly documented. We report a 16-year-old male with a 6.7 Mb deletion (6q25.1–q25.3) presenting with hydrocephalus, cerebral palsy, and severe behavioral dysregulation. Psychiatric evaluation confirmed comorbid ASD (CARS: 52) and ADHD. Behavioral symptoms and aggression were successfully stabilized using 5 mg/day olanzapine. Our case is the first report of ASD/ADHD co-occurrence in 6q25 syndrome highlights the potential neurobehavioral role of genes like ARID1B and SYNE1. Our findings emphasize the need for comprehensive psychiatric evaluation in rare chromosomal aberrations. [ABSTRACT FROM AUTHOR]
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Database: Psychology and Behavioral Sciences Collection
Description
Abstract:6q25 microdeletion is a rare syndrome associated with intellectual disability and dysmorphism. However, comorbid Autism Spectrum Disorder (ASD) and Attention Deficit and Hyperactivity Disorder (ADHD) are poorly documented. We report a 16-year-old male with a 6.7 Mb deletion (6q25.1–q25.3) presenting with hydrocephalus, cerebral palsy, and severe behavioral dysregulation. Psychiatric evaluation confirmed comorbid ASD (CARS: 52) and ADHD. Behavioral symptoms and aggression were successfully stabilized using 5 mg/day olanzapine. Our case is the first report of ASD/ADHD co-occurrence in 6q25 syndrome highlights the potential neurobehavioral role of genes like ARID1B and SYNE1. Our findings emphasize the need for comprehensive psychiatric evaluation in rare chromosomal aberrations. [ABSTRACT FROM AUTHOR]
ISSN:87565641
DOI:10.1080/87565641.2026.2674063