View in EDS

Comorbid Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder in a Patient with 6q25.1–Q25.3 Microdeletion: A Case Report.

Saved in:
Bibliographic Details
Title: Comorbid Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder in a Patient with 6q25.1–Q25.3 Microdeletion: A Case Report.
Authors: Sezgin, Mehmet (AUTHOR), Koyuncu, Oğuzhan (AUTHOR), Güneş, Mustafa (AUTHOR), Yıldırım Budak, Burcu (AUTHOR)
Source: Developmental Neuropsychology. 2026, Vol. 51 Issue 3/4, p207-214. 8p.
Subjects: Autism spectrum disorders, Attention-deficit hyperactivity disorder, DNA copy number variations, Behavior genetics, Emotional stability, Comorbidity, Olanzapine
Abstract: 6q25 microdeletion is a rare syndrome associated with intellectual disability and dysmorphism. However, comorbid Autism Spectrum Disorder (ASD) and Attention Deficit and Hyperactivity Disorder (ADHD) are poorly documented. We report a 16-year-old male with a 6.7 Mb deletion (6q25.1–q25.3) presenting with hydrocephalus, cerebral palsy, and severe behavioral dysregulation. Psychiatric evaluation confirmed comorbid ASD (CARS: 52) and ADHD. Behavioral symptoms and aggression were successfully stabilized using 5 mg/day olanzapine. Our case is the first report of ASD/ADHD co-occurrence in 6q25 syndrome highlights the potential neurobehavioral role of genes like ARID1B and SYNE1. Our findings emphasize the need for comprehensive psychiatric evaluation in rare chromosomal aberrations. [ABSTRACT FROM AUTHOR]
Copyright of Developmental Neuropsychology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 194726014
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Comorbid Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder in a Patient with 6q25.1–Q25.3 Microdeletion: A Case Report.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Sezgin%2C+Mehmet%22">Sezgin, Mehmet</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Koyuncu%2C+Oğuzhan%22">Koyuncu, Oğuzhan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Güneş%2C+Mustafa%22">Güneş, Mustafa</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yıldırım+Budak%2C+Burcu%22">Yıldırım Budak, Burcu</searchLink> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Developmental+Neuropsychology%22">Developmental Neuropsychology</searchLink>. 2026, Vol. 51 Issue 3/4, p207-214. 8p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Autism+spectrum+disorders%22">Autism spectrum disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Attention-deficit+hyperactivity+disorder%22">Attention-deficit hyperactivity disorder</searchLink><br /><searchLink fieldCode="DE" term="%22DNA+copy+number+variations%22">DNA copy number variations</searchLink><br /><searchLink fieldCode="DE" term="%22Behavior+genetics%22">Behavior genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Emotional+stability%22">Emotional stability</searchLink><br /><searchLink fieldCode="DE" term="%22Comorbidity%22">Comorbidity</searchLink><br /><searchLink fieldCode="DE" term="%22Olanzapine%22">Olanzapine</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: 6q25 microdeletion is a rare syndrome associated with intellectual disability and dysmorphism. However, comorbid Autism Spectrum Disorder (ASD) and Attention Deficit and Hyperactivity Disorder (ADHD) are poorly documented. We report a 16-year-old male with a 6.7 Mb deletion (6q25.1–q25.3) presenting with hydrocephalus, cerebral palsy, and severe behavioral dysregulation. Psychiatric evaluation confirmed comorbid ASD (CARS: 52) and ADHD. Behavioral symptoms and aggression were successfully stabilized using 5 mg/day olanzapine. Our case is the first report of ASD/ADHD co-occurrence in 6q25 syndrome highlights the potential neurobehavioral role of genes like ARID1B and SYNE1. Our findings emphasize the need for comprehensive psychiatric evaluation in rare chromosomal aberrations. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Developmental Neuropsychology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=194726014
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/87565641.2026.2674063
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 207
    Subjects:
      – SubjectFull: Autism spectrum disorders
        Type: general
      – SubjectFull: Attention-deficit hyperactivity disorder
        Type: general
      – SubjectFull: DNA copy number variations
        Type: general
      – SubjectFull: Behavior genetics
        Type: general
      – SubjectFull: Emotional stability
        Type: general
      – SubjectFull: Comorbidity
        Type: general
      – SubjectFull: Olanzapine
        Type: general
    Titles:
      – TitleFull: Comorbid Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder in a Patient with 6q25.1–Q25.3 Microdeletion: A Case Report.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Sezgin, Mehmet
      – PersonEntity:
          Name:
            NameFull: Koyuncu, Oğuzhan
      – PersonEntity:
          Name:
            NameFull: Güneş, Mustafa
      – PersonEntity:
          Name:
            NameFull: Yıldırım Budak, Burcu
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: 2026
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 87565641
          Numbering:
            – Type: volume
              Value: 51
            – Type: issue
              Value: 3/4
          Titles:
            – TitleFull: Developmental Neuropsychology
              Type: main
ResultId 1