Bibliographic Details
| Title: |
Autism spectrum disorders associated with X chromosome markers in French-Canadian males. |
| Authors: |
Gauthier, J., Joober, R., Dubé, M. -P., St-Onge, J., Bonnel, A., Gariépy, D., Laurent, S., Najafee, R., Lacasse, H., St-Charles, L., Fombonne, É., Mottron, L., Rouleau, G. A. |
| Source: |
Molecular Psychiatry. Feb2006, Vol. 11 Issue 2, p206-213. 8p. 1 Diagram, 4 Charts. |
| Subjects: |
Autism, X chromosome, Chromosomes, Genetic markers, Developmental disabilities, French-Canadians, Genetic disorders, Medical genetics |
| Abstract: |
It is now well established that genetic factors play an important role in the pathogenesis of autism disorder and converging lines of evidence suggest the implication of the X chromosome. Using a sample of subjects diagnosed with autism spectrum disorders, exclusively composed of males from French-Canadian (FC) origin, we tested markers covering the entire X chromosome using a family-based association study. Our initial analysis revealed the presence of association at two loci: DXS6789 (P=0.026) and DXS8043 (P=0.0101). In a second step, we added support to the association at DXS8043 using additional markers, additional subjects and a haplotype-based analysis (best obtained P-value=0.00001). These results provide support for the existence of a locus on the X chromosome that predisposes the FC to autism spectrum disorders.Molecular Psychiatry (2006) 11, 206–213. doi:10.1038/sj.mp.4001756; published online 1 November 2005 [ABSTRACT FROM AUTHOR] |
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| Database: |
Psychology and Behavioral Sciences Collection |
