View in EDS PDF Full Text

Autism spectrum disorders associated with X chromosome markers in French-Canadian males.

Saved in:
Bibliographic Details
Title: Autism spectrum disorders associated with X chromosome markers in French-Canadian males.
Authors: Gauthier, J., Joober, R., Dubé, M. -P., St-Onge, J., Bonnel, A., Gariépy, D., Laurent, S., Najafee, R., Lacasse, H., St-Charles, L., Fombonne, É., Mottron, L., Rouleau, G. A.
Source: Molecular Psychiatry. Feb2006, Vol. 11 Issue 2, p206-213. 8p. 1 Diagram, 4 Charts.
Subjects: Autism, X chromosome, Chromosomes, Genetic markers, Developmental disabilities, French-Canadians, Genetic disorders, Medical genetics
Abstract: It is now well established that genetic factors play an important role in the pathogenesis of autism disorder and converging lines of evidence suggest the implication of the X chromosome. Using a sample of subjects diagnosed with autism spectrum disorders, exclusively composed of males from French-Canadian (FC) origin, we tested markers covering the entire X chromosome using a family-based association study. Our initial analysis revealed the presence of association at two loci: DXS6789 (P=0.026) and DXS8043 (P=0.0101). In a second step, we added support to the association at DXS8043 using additional markers, additional subjects and a haplotype-based analysis (best obtained P-value=0.00001). These results provide support for the existence of a locus on the X chromosome that predisposes the FC to autism spectrum disorders.Molecular Psychiatry (2006) 11, 206–213. doi:10.1038/sj.mp.4001756; published online 1 November 2005 [ABSTRACT FROM AUTHOR]
Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: pbh
DbLabel: Psychology and Behavioral Sciences Collection
An: 19504460
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Autism spectrum disorders associated with X chromosome markers in French-Canadian males.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Gauthier%2C+J%2E%22">Gauthier, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Joober%2C+R%2E%22">Joober, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Dubé%2C+M%2E+-P%2E%22">Dubé, M. -P.</searchLink><br /><searchLink fieldCode="AR" term="%22St-Onge%2C+J%2E%22">St-Onge, J.</searchLink><br /><searchLink fieldCode="AR" term="%22Bonnel%2C+A%2E%22">Bonnel, A.</searchLink><br /><searchLink fieldCode="AR" term="%22Gariépy%2C+D%2E%22">Gariépy, D.</searchLink><br /><searchLink fieldCode="AR" term="%22Laurent%2C+S%2E%22">Laurent, S.</searchLink><br /><searchLink fieldCode="AR" term="%22Najafee%2C+R%2E%22">Najafee, R.</searchLink><br /><searchLink fieldCode="AR" term="%22Lacasse%2C+H%2E%22">Lacasse, H.</searchLink><br /><searchLink fieldCode="AR" term="%22St-Charles%2C+L%2E%22">St-Charles, L.</searchLink><br /><searchLink fieldCode="AR" term="%22Fombonne%2C+É%2E%22">Fombonne, É.</searchLink><br /><searchLink fieldCode="AR" term="%22Mottron%2C+L%2E%22">Mottron, L.</searchLink><br /><searchLink fieldCode="AR" term="%22Rouleau%2C+G%2E+A%2E%22">Rouleau, G. A.</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Molecular+Psychiatry%22">Molecular Psychiatry</searchLink>. Feb2006, Vol. 11 Issue 2, p206-213. 8p. 1 Diagram, 4 Charts.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Autism%22">Autism</searchLink><br /><searchLink fieldCode="DE" term="%22X+chromosome%22">X chromosome</searchLink><br /><searchLink fieldCode="DE" term="%22Chromosomes%22">Chromosomes</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+markers%22">Genetic markers</searchLink><br /><searchLink fieldCode="DE" term="%22Developmental+disabilities%22">Developmental disabilities</searchLink><br /><searchLink fieldCode="DE" term="%22French-Canadians%22">French-Canadians</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+disorders%22">Genetic disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+genetics%22">Medical genetics</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: It is now well established that genetic factors play an important role in the pathogenesis of autism disorder and converging lines of evidence suggest the implication of the X chromosome. Using a sample of subjects diagnosed with autism spectrum disorders, exclusively composed of males from French-Canadian (FC) origin, we tested markers covering the entire X chromosome using a family-based association study. Our initial analysis revealed the presence of association at two loci: DXS6789 (P=0.026) and DXS8043 (P=0.0101). In a second step, we added support to the association at DXS8043 using additional markers, additional subjects and a haplotype-based analysis (best obtained P-value=0.00001). These results provide support for the existence of a locus on the X chromosome that predisposes the FC to autism spectrum disorders.Molecular Psychiatry (2006) 11, 206–213. doi:10.1038/sj.mp.4001756; published online 1 November 2005 [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Molecular Psychiatry is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=pbh&AN=19504460
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/sj.mp.4001756
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 206
    Subjects:
      – SubjectFull: Autism
        Type: general
      – SubjectFull: X chromosome
        Type: general
      – SubjectFull: Chromosomes
        Type: general
      – SubjectFull: Genetic markers
        Type: general
      – SubjectFull: Developmental disabilities
        Type: general
      – SubjectFull: French-Canadians
        Type: general
      – SubjectFull: Genetic disorders
        Type: general
      – SubjectFull: Medical genetics
        Type: general
    Titles:
      – TitleFull: Autism spectrum disorders associated with X chromosome markers in French-Canadian males.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Gauthier, J.
      – PersonEntity:
          Name:
            NameFull: Joober, R.
      – PersonEntity:
          Name:
            NameFull: Dubé, M. -P.
      – PersonEntity:
          Name:
            NameFull: St-Onge, J.
      – PersonEntity:
          Name:
            NameFull: Bonnel, A.
      – PersonEntity:
          Name:
            NameFull: Gariépy, D.
      – PersonEntity:
          Name:
            NameFull: Laurent, S.
      – PersonEntity:
          Name:
            NameFull: Najafee, R.
      – PersonEntity:
          Name:
            NameFull: Lacasse, H.
      – PersonEntity:
          Name:
            NameFull: St-Charles, L.
      – PersonEntity:
          Name:
            NameFull: Fombonne, É.
      – PersonEntity:
          Name:
            NameFull: Mottron, L.
      – PersonEntity:
          Name:
            NameFull: Rouleau, G. A.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 02
              Text: Feb2006
              Type: published
              Y: 2006
          Identifiers:
            – Type: issn-print
              Value: 13594184
          Numbering:
            – Type: volume
              Value: 11
            – Type: issue
              Value: 2
          Titles:
            – TitleFull: Molecular Psychiatry
              Type: main
ResultId 1