View in EDS

Outcome and cost‐effectiveness of transdiagnostic cognitive behavioral therapy compared with management as usual for youth with common mental health problems: Long‐term results from the Mind‐My‐Mind randomized trial.

Saved in:
Bibliographic Details
Title: Outcome and cost‐effectiveness of transdiagnostic cognitive behavioral therapy compared with management as usual for youth with common mental health problems: Long‐term results from the Mind‐My‐Mind randomized trial.
Authors: Vassard, Ditte (AUTHOR), Rimvall, Martin Køster (AUTHOR), Wolf, Rasmus Trap (AUTHOR), Christensen, Robin (AUTHOR), Nielsen, Sabrina M. (AUTHOR), Plessen, Kerstin Jessica (AUTHOR), Verhulst, Frank (AUTHOR), Bilenberg, Niels (AUTHOR), Thomsen, Per Hove (AUTHOR), Thastum, Mikael (AUTHOR), Neumer, Simon‐Peter (AUTHOR), Pagsberg, Anne Katrine (AUTHOR), Silverman, Wendy K. (AUTHOR), Correll, Christoph U. (AUTHOR), Jeppesen, Pia (AUTHOR)
Source: Journal of Child Psychology & Psychiatry. Aug2026, Vol. 67 Issue 8, p1307-1320. 14p.
Subjects: Mental illness treatment, Psychotherapy, Quality-adjusted life years, Cost effectiveness, Research funding, Health status indicators, Statistical sampling, Questionnaires, Logistic regression analysis, Treatment effectiveness, Randomized controlled trials, Descriptive statistics, Longitudinal method, Odds ratio, Behavior disorders in children, Quality of life, Cognitive therapy, Confidence intervals, Health outcome assessment, Data analysis software, Anxiety disorders, Proportional hazards models, Sensitivity & specificity (Statistics), Mental depression, Medical care costs, Evaluation, Adolescence, Children
Geographic Terms: Germany
Abstract: Background: Credible long‐term outcomes from randomized trials evaluating the effectiveness and cost‐effectiveness of preventive programs for mental health problems are needed. We compared long‐term effects of the Mind My Mind (MMM) transdiagnostic cognitive behavioral therapy (CBT) program to management as usual (MAU). Methods: The study was a pragmatic, multisite, randomized superiority trial (2017–2019) involving youths aged 6–16 years with anxiety, depressive symptoms, and/or behavioral disturbances, recruited through family self‐referral. The MMM intervention included 9–13 weekly CBT sessions. The primary outcome was change from baseline in parent‐reported impact of mental health problems at 3‐year follow‐up post‐randomization using the Strengths and Difficulties Questionnaire (SDQ) impact scale. Register‐based outcomes tracked youths' psychiatric diagnoses in mental health services. To assess cost‐effectiveness, we calculated the incremental costs and incremental quality‐adjusted life years (QALYs). All primary analyses followed the intention‐to‐treat (ITT) approach. Clinical trials registration: ID NCT04804917. Results: Among 396 youths randomized (baseline mean [SD] age, 10.3 [2.4] years; 52.0% boys; MMM n = 197, MAU n = 199), the 3‐year follow‐up (median 167 weeks; range 124–203 weeks) primary outcome data were available in 69.0% and 59.3%, respectively. The decrease in SDQ‐impact‐score from baseline to 3‐year follow‐up (4.12→1.79 points [MMM] and 4.21→1.85 [MAU]) was similar (between‐group difference, 0.06 [95% CI −0.41 to 0.52]; p =.81). An equal proportion (25%) of youths in MMM and MAU were diagnosed with any mental disorder during follow‐up (HR 1.01, 95% CI 0.68–1.50). Total costs over the intervention period were higher in the MMM group (incremental costs 3,014 Euros [95% CI: 2.174–3.855]). Cost‐effectiveness analyses favored MMM: QALY net gain 0.121 (95% CI 0.045–0.196); the cost‐effectiveness ratio was 24,789 Euro/QALY. Conclusions: Although MMM was potentially cost‐effective, the beneficial effects diminished over 3 years post‐treatment. The findings highlight the need for strategies to sustain long‐term effects. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Child Psychology & Psychiatry is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Psychology and Behavioral Sciences Collection
Description
Abstract:Background: Credible long‐term outcomes from randomized trials evaluating the effectiveness and cost‐effectiveness of preventive programs for mental health problems are needed. We compared long‐term effects of the Mind My Mind (MMM) transdiagnostic cognitive behavioral therapy (CBT) program to management as usual (MAU). Methods: The study was a pragmatic, multisite, randomized superiority trial (2017–2019) involving youths aged 6–16 years with anxiety, depressive symptoms, and/or behavioral disturbances, recruited through family self‐referral. The MMM intervention included 9–13 weekly CBT sessions. The primary outcome was change from baseline in parent‐reported impact of mental health problems at 3‐year follow‐up post‐randomization using the Strengths and Difficulties Questionnaire (SDQ) impact scale. Register‐based outcomes tracked youths' psychiatric diagnoses in mental health services. To assess cost‐effectiveness, we calculated the incremental costs and incremental quality‐adjusted life years (QALYs). All primary analyses followed the intention‐to‐treat (ITT) approach. Clinical trials registration: ID NCT04804917. Results: Among 396 youths randomized (baseline mean [SD] age, 10.3 [2.4] years; 52.0% boys; MMM n = 197, MAU n = 199), the 3‐year follow‐up (median 167 weeks; range 124–203 weeks) primary outcome data were available in 69.0% and 59.3%, respectively. The decrease in SDQ‐impact‐score from baseline to 3‐year follow‐up (4.12→1.79 points [MMM] and 4.21→1.85 [MAU]) was similar (between‐group difference, 0.06 [95% CI −0.41 to 0.52]; p =.81). An equal proportion (25%) of youths in MMM and MAU were diagnosed with any mental disorder during follow‐up (HR 1.01, 95% CI 0.68–1.50). Total costs over the intervention period were higher in the MMM group (incremental costs 3,014 Euros [95% CI: 2.174–3.855]). Cost‐effectiveness analyses favored MMM: QALY net gain 0.121 (95% CI 0.045–0.196); the cost‐effectiveness ratio was 24,789 Euro/QALY. Conclusions: Although MMM was potentially cost‐effective, the beneficial effects diminished over 3 years post‐treatment. The findings highlight the need for strategies to sustain long‐term effects. [ABSTRACT FROM AUTHOR]
ISSN:00219630
DOI:10.1111/jcpp.70128